The impact of Helicobacter pylori on gastric cancer formation and early warning signal identification.

IF 3.1 2区化学 Q3 CHEMISTRY, PHYSICAL

Journal of Chemical Physics Pub Date : 2024-12-21 DOI:10.1063/5.0243016

Chong Yu, Jin Wang

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引用次数: 0

Abstract

Gastric cancer is highly prevalent in Asia and is characterized by poor prognosis post-surgery and a high recurrence rate within five years. Research has highlighted the role of Helicobacter pylori in initiating or accelerating gastric cancer development. However, quantitative analysis of its impact on gastric cancer carcinogenesis is still lacking. This study employs gene regulatory networks and landscape and flux theory, integrating genetic and epigenetic factors, to quantitatively elucidate how Helicobacter pylori influences gastric cancer progression. Varied Helicobacter pylori infection concentrations lead to significant shifts in system thermodynamic and dynamic driving forces, altering gene expression levels. Quantitative analysis of entropy production rate and mean-flux in the gastric cancer system reveals the global changes in thermodynamic and dynamic driving forces. Coupled with autocorrelation, cross correlation, and variance analysis, we pinpoint critical stages of Helicobacter pylori infection, serving as early warning signals for gastric cancer. This approach bridges theoretical and clinical realms, dynamically assessing Helicobacter pylori's impact on gastric cancer and identifying crucial early warning signals, with significant clinical and translational implications.

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幽门螺杆菌对胃癌形成及预警信号识别的影响。

胃癌在亚洲发病率高，术后预后差，5年内复发率高。研究强调了幽门螺杆菌在启动或加速胃癌发展中的作用。然而，其对胃癌发生的影响尚缺乏定量分析。本研究运用基因调控网络和景观通量理论，整合遗传和表观遗传因素，定量阐明幽门螺杆菌对胃癌进展的影响。不同的幽门螺杆菌感染浓度导致系统热力学和动力驱动力的显著变化，改变基因表达水平。定量分析胃癌系统的熵产率和平均通量，揭示了其热力学和动力学驱动力的全局变化。结合自相关、交叉相关和方差分析，我们确定了幽门螺杆菌感染的关键阶段，作为胃癌的早期预警信号。该方法连接了理论和临床领域，动态评估幽门螺杆菌对胃癌的影响，识别关键的早期预警信号，具有重要的临床和转化意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Physics 物理-物理：原子、分子和化学物理

CiteScore

7.40

自引率

15.90%

发文量

1615

审稿时长

2 months

期刊介绍： The Journal of Chemical Physics publishes quantitative and rigorous science of long-lasting value in methods and applications of chemical physics. The Journal also publishes brief Communications of significant new findings, Perspectives on the latest advances in the field, and Special Topic issues. The Journal focuses on innovative research in experimental and theoretical areas of chemical physics, including spectroscopy, dynamics, kinetics, statistical mechanics, and quantum mechanics. In addition, topical areas such as polymers, soft matter, materials, surfaces/interfaces, and systems of biological relevance are of increasing importance. Topical coverage includes: Theoretical Methods and Algorithms Advanced Experimental Techniques Atoms, Molecules, and Clusters Liquids, Glasses, and Crystals Surfaces, Interfaces, and Materials Polymers and Soft Matter Biological Molecules and Networks.