A fatal case of Vibrio cholerae-associated diarrhea and bacteremia in a 30-year-old carrier of beta-thalassemia.

Abstract

Bacterial infections leading to bacteremia and septicemic shock constitute an emerging public health concern globally, especially in areas where sanitation is poor and safe drinking water is scarce. Enteric pathogens such as Vibrio cholerae are responsible for many deaths caused by contaminated food and water in these areas. While cholera is the prominent clinical threat posed by V. cholerae, outcomes like bacteremia turning into sepsis and associated morbidity and mortality have been increasing globally in recent times. Here, we report an alarming case of fatal sepsis with a probable association of V. cholerae bacteremia in Bangladesh. In September 2023, a 30-year-old man with a pre-condition of beta-thalassemia presented to a tertiary care hospital with acute diarrhea, abdominal pain, nausea, and fever and died within 36 h of admission with acute cholecystitis, metabolic acidosis, acute kidney injury, pancytopenia, and refractory septic shock with multi-organ dysfunction syndrome. Blood culture detected V. cholerae, which was further characterized as hemolytic, carrying the hemolysin gene and genes for the virulence factor type-three secretion system. The isolate was confirmed as V. cholerae non-O1/O139 (NOVC), which differed in genetic properties from the few contemporary NOVC isolates associated with diarrheal cases in Bangladesh. To manage the diarrhea and septicemic condition, the patient was treated empirically with metronidazole and meropenem. However, antibiotic susceptibility testing showed the strain was susceptible to all the routinely prescribed drugs for V. cholerae infections. To the best of our knowledge, this investigation provides the first molecular description of a fatal case of V. cholerae-associated bacteremia in Bangladesh and underscores the need for comprehensive investigations on bacterial septicemia to prevent future casualties.