Characteristics of lipid metabolism and fat distribution in patients with primary hyperparathyroidism and their Mendelian randomization study.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2024-12-19 DOI:10.1007/s12020-024-04141-3

Ying Zhang, Min Yang, Yinqiong Wu, Qin Wang

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引用次数: 0

Abstract

Objective: Primary hyperparathyroidism (PHPT) is characterized by elevated parathyroid hormone (PTH) levels and hypercalcemia. Although research suggests a potential link between PTH and lipid metabolism, the evidence remains inconclusive. This study investigated lipid metabolism and fat distribution in PHPT patients.

Methods: We studied 157 PHPT patients and strictly matched 1:1 controls based on sex, age, and BMI from our hospital (2020-2023). We recorded clinical data and used quantitative computed tomography (QCT) to measure lumbar spine bone mineral density and assess visceral and subcutaneous fat areas. Mendelian randomization analysis, utilizing genome-wide association study (GWAS) data, investigated the causal relationships between PHPT and various anthropometric measures, including body mass index (BMI), waist-to-hip ratio (WHR), and waist circumference (WC). Additionally, the analysis examined the associations between PTH levels and these same anthropometric traits: BMI, WHR, and WC.

Results: The study included 47 males and 110 females in each group. There were no statistically significant differences between the two groups regarding BMI, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total fat area (TFA), abdominal visceral fat area (VFA), subcutaneous fat area (SFA), or the VFA/SFA ratio (P > 0.05). After adjusting for albumin-corrected calcium, estimated glomerular filtration rate (eGFR), and 25-hydroxyvitamin D (25OHD), correlations between PTH and BMI, TG, TC, HDL-C, LDL-C, and the VFA/SFA ratio were not significant in either group (P > 0.05). Furthermore, when all the study subjects were divided into three groups based on PTH tertiles, correlations between PTH and the aforementioned indices remained nonsignificant after adjusting for albumin-corrected calcium, eGFR, and 25OHD (P > 0.05). In a two-sample Mendelian randomization study, no significant associations were observed between PHPT and BMI, WHR, or WC. Similarly, no significant associations were identified between PTH levels and BMI, WHR, or WC.

Conclusions: No statistically significant disparities were discerned in lipid metabolism markers or fat distribution between PHPT patients and controls. No significant correlation exists between PTH levels and lipid metabolism or fat distribution. Furthermore, no causal relationship was established between PHPT and BMI, WHR, or WC, nor between PTH levels and these anthropometric measures.

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原发性甲状旁腺功能亢进患者脂质代谢和脂肪分布特征及其孟德尔随机化研究。

目的：原发性甲状旁腺功能亢进症（PHPT原发性甲状旁腺功能亢进症（PHPT）的特点是甲状旁腺激素（PTH）水平升高和高钙血症。尽管研究表明 PTH 与脂质代谢之间存在潜在联系，但证据仍不明确。本研究调查了PHPT患者的脂质代谢和脂肪分布：我们研究了本院（2020-2023 年）的 157 名 PHPT 患者和根据性别、年龄和体重指数 1:1 严格匹配的对照组。我们记录了临床数据，并使用定量计算机断层扫描（QCT）测量了腰椎骨矿物质密度，评估了内脏和皮下脂肪面积。孟德尔随机分析利用全基因组关联研究（GWAS）数据，研究了 PHPT 与各种人体测量指标（包括体重指数（BMI）、腰臀比（WHR）和腰围（WC））之间的因果关系。此外，分析还研究了 PTH 水平与这些相同人体测量特征之间的关系：结果：研究包括每组 47 名男性和 110 名女性。两组在体重指数（BMI）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总脂肪面积（TFA）、腹部内脏脂肪面积（VFA）、皮下脂肪面积（SFA）或VFA/SFA比值方面均无统计学差异（P > 0.05）。在对白蛋白校正钙、估计肾小球滤过率（eGFR）和 25- 羟维生素 D（25OHD）进行调整后，PTH 与 BMI、TG、TC、HDL-C、LDL-C 和 VFA/SFA 比值之间的相关性在两组中均不显著（P > 0.05）。此外，将所有研究对象按 PTH 三等分法分为三组，在调整白蛋白校正钙、eGFR 和 25OHD 后，PTH 与上述指标之间的相关性仍然不显著（P > 0.05）。在一项双样本孟德尔随机研究中，未观察到 PHPT 与体重指数（BMI）、WHR 或 WC 之间存在显著关联。同样，PTH 水平与 BMI、WHR 或 WC 之间也未发现明显关联：PHPT患者和对照组之间在脂质代谢指标或脂肪分布方面没有发现明显的统计学差异。PTH水平与脂质代谢或脂肪分布之间不存在明显的相关性。此外，PHPT 与 BMI、WHR 或 WC 之间，以及 PTH 水平与这些人体测量指标之间都没有因果关系。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.