Carotid artery intima-media thickness values in obese or overweight children: a meta-analysis.

IF 4.7 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Radiology Pub Date : 2025-06-01 Epub Date: 2024-12-19 DOI:10.1007/s00330-024-11284-4

Jean-Baptiste Moretti, Alexandre Korban, Émilie Alchourron, Sylvie Gervais, Ramy El Jalbout

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引用次数: 0

Abstract

Objective: Carotid artery intima-media thickness (IMT) is a non-invasive ultrasound marker of early atherosclerosis. This systematic review and meta-analysis aim to report the published differences in IMT values in children living with overweight or obesity compared to controls with normal weight.

Methods: This review was conducted according to PRISMA guidelines, including only cohorts with normal controls. Inclusion criteria were IMT measured using B-mode or radiofrequency (RF) techniques and based on the four consensuses: American Heart Association, Association for European Pediatric Cardiology, Mannheim Consensus, and American Society of Echocardiography. We used the body mass index based on the World Health Organization growth standard definitions of obesity in children. Relevant articles were extracted from PubMed, Cochrane Library, Embase, and Web of Science searched from inception to February 2024. A meta-analysis was done by a biostatistician using the R-software version 4.0.2.

Results: We obtained 15 B-mode-based and two RF echo-tracking-based IMT measurement studies. IMT is significantly increased in children living with obesity. The mean IMT was 0.041 mm, 95% confidence interval (CI): 0.052; 0.031 higher in children with overweight/obesity, using the B-mode technique, and 0.045 mm, 95% CI: 0.062; 0.029 higher in children with overweight/obesity using RF technique.

Conclusion: This meta-analysis shows that IMT is significantly increased in children with obesity compared to normal-weight children according to both techniques.

Key points: Question IMT measured according to known consensuses is significantly increased in children living with obesity. Findings Mean IMT was 0.041 mm higher in children living with obesity using the B-mode technique and 0.045 mm using the RF technique. Clinical relevance There are different techniques to measure IMT in children. This meta-analysis, using cohorts of children living with obesity compared to normal weight controls, shows a significantly increased IMT in children living with obesity.

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肥胖或超重儿童颈动脉内膜-中膜厚度值：荟萃分析。

目的：颈动脉内膜-中膜厚度（IMT）是早期动脉粥样硬化的无创超声指标。本系统综述和荟萃分析旨在报告已发表的超重或肥胖儿童与正常体重对照组相比IMT值的差异。方法：本综述按照PRISMA指南进行，仅包括正常对照的队列。纳入标准是使用b模式或射频（RF）技术测量IMT，并基于四个共识：美国心脏协会、欧洲儿科心脏病学会、曼海姆共识和美国超声心动图学会。我们使用的体重指数是基于世界卫生组织对儿童肥胖的生长标准定义。相关文章提取自PubMed、Cochrane Library、Embase和Web of Science，检索时间为建站至2024年2月。生物统计学家使用r软件4.0.2版进行meta分析。结果：我们获得了15项基于b模式和2项基于射频回波跟踪的IMT测量研究。肥胖儿童的IMT显著增加。平均IMT为0.041 mm， 95%可信区间（CI）： 0.052；使用b模式技术，超重/肥胖儿童高0.031 mm，和0.045 mm, 95% CI: 0.062；使用射频技术的超重/肥胖儿童的死亡率高出0.029。结论：本荟萃分析显示，与体重正常的儿童相比，采用这两种技术的肥胖儿童的IMT显著增加。根据已知共识测量的IMT在肥胖儿童中显著增加。发现肥胖儿童的平均IMT使用B-mode技术高出0.041 mm，使用RF技术高出0.045 mm。有不同的技术来测量儿童IMT。这项荟萃分析将肥胖儿童与体重控制正常的儿童进行了比较，结果显示肥胖儿童的IMT显著增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Radiology 医学-核医学

CiteScore

11.60

自引率

8.50%

发文量

874

审稿时长

2-4 weeks

期刊介绍： European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.