Flexibility of intrinsic neural timescales during distinct behavioral states

IF 5.2 1区 生物学 Q1 BIOLOGY
Yasir Çatal, Kaan Keskin, Angelika Wolman, Philipp Klar, David Smith, Georg Northoff
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Abstract

Recent neuroimaging studies demonstrate a heterogeneity of timescales prevalent in the brain’s ongoing spontaneous activity, labeled intrinsic neural timescales (INT). At the same time, neural timescales also reflect stimulus- or task-related activity. The relationship of the INT during the brain’s spontaneous activity with their involvement in task states including behavior remains unclear. To address this question, we combined calcium imaging data of spontaneously behaving mice and human electroencephalography (EEG) during rest and task states with computational modeling. We obtained four primary findings: (i) the distinct behavioral states can be accurately predicted from INT, (ii) INT become longer during behavioral states compared to rest, (iii) INT change from rest to task is correlated negatively with the variability of INT during rest, (iv) neural mass modeling shows a key role of recurrent connections in mediating the rest-task change of INT. Extending current findings, our results show the dynamic nature of the brain’s INT in reflecting continuous behavior through their flexible rest-task modulation possibly mediated by recurrent connections. Calcium imaging of spontaneously behaving mice show increased intrinsic neural timescales during behavior. The behavioral state of mice can be predicted from the topography of timescales of the cortex. Findings are replicated on a human EEG dataset. Mathematical modeling shows the role of recurrent connections for the change in timescales.

Abstract Image

不同行为状态下内在神经时间尺度的灵活性。
最近的神经影像学研究表明,在大脑正在进行的自发活动中普遍存在时间尺度的异质性,称为内在神经时间尺度(INT)。同时,神经时间标度也反映了刺激或任务相关的活动。在大脑自发活动中,INT与包括行为在内的任务状态的关系尚不清楚。为了解决这个问题,我们将自发行为小鼠和人类在休息和任务状态下的脑电图(EEG)的钙成像数据与计算建模相结合。我们得到了四个主要发现:(1)不同的行为状态可以通过INT准确预测;(2)与休息相比,行为状态下的INT变长;(3)从休息到任务的INT变化与休息期间INT的变异性呈负相关;(4)神经质量模型显示了循环连接在调节INT的休息-任务变化中的关键作用。扩展目前的发现,我们的研究结果表明,大脑的INT的动态性质,反映连续的行为,通过其灵活的休息-任务调节可能由循环连接介导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Communications Biology
Communications Biology Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
1.70%
发文量
1233
审稿时长
13 weeks
期刊介绍: Communications Biology is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the biological sciences. Research papers published by the journal represent significant advances bringing new biological insight to a specialized area of research.
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