Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-12-15 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S490347

Sumei Li, Xingye Wu, Jingming Yu, Jiaqin Jiang, Ruibing Qi, Bing Chen, Zhengming Li

{"title":"Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study.","authors":"Sumei Li, Xingye Wu, Jingming Yu, Jiaqin Jiang, Ruibing Qi, Bing Chen, Zhengming Li","doi":"10.2147/DMSO.S490347","DOIUrl":null,"url":null,"abstract":"Objective: The aim of the present study was to investigate how thyroid hormone levels are related to controlled attenuation parameters (CAP), which may provide insights for understanding the role of these factors in hepatic steatosis.Methods: A total of 3461 participants who underwent CAP diagnosis between 2018 and 2023 were included. The associations between thyroid hormone levels and CAP were evaluated through multiple linear regression, restricted cubic splines (RCS) and threshold effect analyses.Results: Multiple linear regression analysis revealed an inverse relationship between free thyroxine (FT4) and CAP, with a coefficient of -0.855 and a confidence interval of -1.297 to -0.412. The negative connection in a subset examination persisted in males [-0.729 (-1.295, -0.162)] and females [-1.234 (-1.996, -0.473)]. A strong correlation was found between free 3,5,3'-triiodothyronine (FT3) and CAP, with values of 2.182 (1.154, 3.211). Further analysis was conducted on both male [1.626 (0.188, 3.065)] and female [2.835 (1.137, 4.533)] subgroups. In the severe liver steatosis group, there was a significant negative correlation between FT3 and CAP based on the subgroup analysis stratified by the level of liver steatosis [-3.804 (-6.711, -0.898)]. The RCS analysis showed a nonlinear association between FT4 and CAP, with a turning point at 11.14 pmol/L.Conclusion: There was a significant linear and nonlinear relationship between FT4, FT3 and CAP. Thyroid hormones could have a significant impact on liver steatosis, offering fresh perspectives on how to prevent and treat this condition.","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4777-4787"},"PeriodicalIF":2.8000,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658957/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DMSO.S490347","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of the present study was to investigate how thyroid hormone levels are related to controlled attenuation parameters (CAP), which may provide insights for understanding the role of these factors in hepatic steatosis.

Methods: A total of 3461 participants who underwent CAP diagnosis between 2018 and 2023 were included. The associations between thyroid hormone levels and CAP were evaluated through multiple linear regression, restricted cubic splines (RCS) and threshold effect analyses.

Results: Multiple linear regression analysis revealed an inverse relationship between free thyroxine (FT4) and CAP, with a coefficient of -0.855 and a confidence interval of -1.297 to -0.412. The negative connection in a subset examination persisted in males [-0.729 (-1.295, -0.162)] and females [-1.234 (-1.996, -0.473)]. A strong correlation was found between free 3,5,3'-triiodothyronine (FT3) and CAP, with values of 2.182 (1.154, 3.211). Further analysis was conducted on both male [1.626 (0.188, 3.065)] and female [2.835 (1.137, 4.533)] subgroups. In the severe liver steatosis group, there was a significant negative correlation between FT3 and CAP based on the subgroup analysis stratified by the level of liver steatosis [-3.804 (-6.711, -0.898)]. The RCS analysis showed a nonlinear association between FT4 and CAP, with a turning point at 11.14 pmol/L.

Conclusion: There was a significant linear and nonlinear relationship between FT4, FT3 and CAP. Thyroid hormones could have a significant impact on liver steatosis, offering fresh perspectives on how to prevent and treat this condition.

查看原文本刊更多论文

甲状腺激素与受控衰减参数之间的相关性：基于人群的横断面研究

目的：本研究旨在探讨甲状腺激素水平与控制衰减参数（CAP）的关系，为了解这些因素在肝脂肪变性中的作用提供见解。方法：共纳入2018年至2023年期间接受CAP诊断的3461名参与者。通过多元线性回归、限制性三次样条（RCS）和阈值效应分析评估甲状腺激素水平与CAP之间的关系。结果：多元线性回归分析显示游离甲状腺素（FT4）与CAP呈负相关，相关系数为-0.855，置信区间为-1.297 ~ -0.412。在亚群检查中，男性[-0.729(-1.295,-0.162)]和女性[-1.234(-1.996,-0.473)]仍然呈负相关。游离的3,5,3′-三碘甲状腺原氨酸（FT3）与CAP有较强的相关性，其值分别为2.182（1.154,3.211）。对男性亚群[1.626(0.188,3.065)]和女性亚群[2.835(1.137,4.533)]进行进一步分析。重度肝脂肪变性组中，按肝脂肪变性程度分层的亚组分析，FT3与CAP呈显著负相关[-3.804(-6.711,-0.898)]。RCS分析显示，FT4与CAP之间存在非线性关联，在11.14 pmol/L时出现拐点。结论：FT4、FT3与肝脂肪变性之间存在显著的线性和非线性关系。甲状腺激素可能对肝脂肪变性有显著影响，为如何预防和治疗肝脂肪变性提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.