The Effect of Tamsulosin on Iris Morphology, Ciliary Muscle Thickness, and Pupil Diameter

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2024-12-17 DOI:10.1016/j.ajo.2024.12.011

CANER ÖZTÜRK , SELIM CEVHER , MUSTAFA DURAN , MUSA EKICI

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引用次数: 0

Abstract

Purpose

To investigate the effect of tamsulosin on iris morphology, ciliary muscle thickness (CMT), pupil diameter (PD), and pupil responses to light using anterior segment optical coherence tomography and corneal topography.

Design

Prospective clinical before-and-after study

Methods

The right eyes of 43 patients with newly diagnosed benign prostatic hyperplasia were included in this study. Iris dilator muscle region (DMR) thickness, sphincter muscle region (SMR) thickness, DMR/SMR ratio, PD (scotopic, mesopic and photopic light conditions), CMT1 (1 mm posterior to the scleral spur), CMT2 (2 mm posterior to the scleral spur), CMT3 (3 mm posterior to the scleral spur) and anterior chamber depth (ACD) were measured before and after dilation. Measurements were performed twice firstly before starting tamsulosin treatment and secondly at the 3rd month of tamsulosin treatment.

Results

Pre-dilation DMR thickness (P < .001), post-dilation DMR thickness (P < .001) pre-dilation DMR/SMR ratio (P = .001), and post-dilation DMR/SMR ratio (P = .001) were reduced significantly after tamsulosin treatment. Pre-dilation PD decreased after treatment in scotopic, mesopic and photopic conditions, but only photopic conditions showed a significant difference (P = .733, P = .142, and P = .04, respectively). Post-dilation PD was significantly reduced after tamsulosin treatment (P < .001). No significant differences were found in pre- and post-dilation iris SMR thickness (P = .08 and P = .784, respectively), pre-dilation CMT1, CMT2, and CMT3 (P = .841, 0.794, 0.880, respectively), post-dilation CMT1, CMT2, and CMT3 (P = .367, 0.114, 0.256, respectively), pupil dilation speed (P = .463), pre-dilation ACD (P = .583), and post-dilation ACD(P = .305) after treatment.

Conclusion

Tamsulosin treatment does not change the iris SMR thickness, CMT1, CMT2, CMT3, and ACD but statistically significantly reduces the iris DMR thickness, DMR/SMR ratio, pre-dilation photopic PD, and post-dilation PD.

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坦索罗辛对虹膜形态、睫状肌厚度和瞳孔直径的影响。

目的：利用角膜前段光学相干断层扫描和角膜地形图研究坦索罗辛对虹膜形态、睫状肌厚度（CMT）、瞳孔直径（PD）和瞳孔对光反应的影响。设计：前瞻性临床前后对照研究方法：选取43例新诊断的良性前列腺增生患者的右眼作为研究对象。测量虹膜扩张肌区（DMR）厚度、括约肌区（SMR）厚度、DMR/SMR比值、PD（暗、中、光条件）、CMT1（巩膜骨刺后1 mm）、CMT2（巩膜骨刺后2 mm）、CMT3（巩膜骨刺后3 mm）和扩张前后前房深度（ACD）。在开始坦索罗辛治疗前和坦索罗辛治疗第3个月进行两次测量。结论：坦索罗辛治疗对虹膜SMR厚度、CMT1、CMT2、CMT3、ACD无显著影响，但对虹膜DMR厚度、DMR/SMR比值、扩张前光位PD、扩张后PD均有统计学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.