THE EFFECT OF TAMSULOSIN ON IRIS MORPHOLOGY, CILIARY MUSCLE THICKNESS, AND PUPIL DIAMETER.

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2024-12-17 DOI:10.1016/j.ajo.2024.12.011

Caner Öztürk, Selim Cevher, Mustafa Duran, Musa Ekici

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引用次数: 0

Abstract

Purpose: To investigate the effect of tamsulosin on iris morphology, ciliary muscle thickness (CMT), pupil diameter (PD), and pupil responses to light using anterior segment optical coherence tomography and corneal topography.

Design: Prospective clinical before-and-after study METHODS: The right eyes of 43 patients with newly diagnosed benign prostatic hyperplasia were included in this study. Iris dilator muscle region (DMR) thickness, sphincter muscle region (SMR) thickness, DMR/SMR ratio, PD (scotopic, mesopic and photopic light conditions), CMT1(1 mm posterior to the scleral spur), CMT2(2 mm posterior to the scleral spur), CMT3(3 mm posterior to the scleral spur) and anterior chamber depth(ACD) were measured before and after dilation. Measurements were performed twice firstly before starting tamsulosin treatment and secondly at the 3rd month of tamsulosin treatment.

Results: Pre-dilation DMR thickness (p<0.001), post-dilation DMR thickness (p<0.001) pre-dilation DMR/SMR ratio (p=0.001), and post-dilation DMR/SMR ratio (p=0.001) were reduced significantly after tamsulosin treatment. Pre-dilation PD decreased after treatment in scotopic, mesopic and photopic conditions, but only photopic conditions showed a significant difference (p=0.733, p=0.142, and p=0.04,respectively). Post-dilation PD was significantly reduced after tamsulosin treatment (p<0.001). No significant differences were found in pre- and post dilation iris SMR thickness (p=0.08 and p=0.784,respectively), pre-dilation CMT1, CMT2, and CMT3(p=0.841, 0.794, 0.880,respectively), post-dilation CMT1, CMT2, and CMT3 (p=0.367, 0.114, 0.256,respectively), pupil dilation speed (p=0.463), pre-dilation ACD (p=0.583), and post-dilation ACD(p=0.305) after treatment.

Conclusion: Tamsulosin treatment does not change the iris SMR thickness, CMT1, CMT2,CMT3, and ACD but statistically significantly reduces the iris DMR thickness, DMR/SMR ratio, pre-dilation photopic PD, and post-dilation PD.

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.