Radical C4−H Arylation of 1,4-Dihydropyridines with Cyanoarenes

IF 1.5 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Helvetica Chimica Acta Pub Date : 2024-11-20 DOI:10.1002/hlca.202400162

Huaixuan Guo, Shiqin Qiu, Peng Xu

引用次数: 0

Abstract

4-Aryl-1,4-dihydropyridines are prevalent pharmacophores and versatile building blocks in medicinal and synthetic chemistry. Herein, we demonstrated a mechanistically distinct radical-radical cross-coupling approach to 4-aryl-1,4-dihydropyridines, via direct C4−H arylation of 1,4-dihydropyridines with readily available cyanoarenes. This mild protocol is initiated by the direct photoexcitation of 1,4-dihydropyridines, eliminating the need for expensive photocatalysts and enabling operation under ambient air conditions.

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1,4-二氢吡啶与氰芳烃的自由基C4−H芳基化反应

4-芳基-1,4-二氢吡啶是药物和合成化学中常用的药源和多功能构建基块。在这里，我们通过 1,4-二氢吡啶与容易获得的氰基烯烃的直接 C4-H 芳基化反应，展示了一种机制独特的自由基-自由基交叉偶联方法。这种温和的方法由 1,4-二氢吡啶的直接光激发启动，无需昂贵的光催化剂，可在环境空气条件下进行操作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helvetica Chimica Acta 化学-化学综合

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.