Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs-Mediated Mitochondrial Transfer (Adv. Sci. 47/2024)
Xin He, Li Zhong, Nan Wang, Baiwei Zhao, Yannan Wang, Xinxiang Wu, Changyu Zheng, Yueheng Ruan, Jianfeng Hou, Yusheng Luo, Yuehan Yin, Yulong He, Andy Peng Xiang, Jiancheng Wang
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引用次数: 0
Abstract
Gastric Cancer
The cover image shows Earth representing a gastric cancer (GC) cell, surrounded by multiple satellites symbolizing mesenchymal stromal cells (MSCs) in the tumor microenvironment. Numerous meteors, representing the chemotherapy drug oxaliplatin (OXA), are heading toward Earth. However, spacecraft from the satellites (mitochondrial transfer) create a protective shield, altering the path of the meteors and preventing the collision. This artwork vividly captures Yulong He, Andy Peng Xiang, Jiancheng Wang, and co-workers' discovery that mitochondrial transfer from MSCs to GC cells restores mitochondrial function, reduces mitophagy, and leads to OXA resistance. More details can be found in article number 2404994. The cover art was created by Coloring Guangzhou.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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