Evaluating the Role of Leakage Correction of Hemodynamic Parameters derived from Dynamic Contrast Enhanced MRI for Glioma Grading

Abstract

SHOWS STRUCTURAL IMAGES AND VARIOUS PARAMETER MAPS COMPUTED USING FIRST-PASS ANALYSIS, CTUM AND PATLAK-MODEL (B–J) IN A PATIENT WITH IDH WILD TYPE GLIOBLASTOMA. (A) POSTCONTRAST T1-W, (B) RCBF, (C) RCBV, (D) FLAIR, (E) RCBF_CORR, (F) RCBV_CORR, (G) RVP (PATLAK-MODEL), AND (H) RFP. CTUM= COMPARTMENTAL TISSUE UPTAKE MODEL; CBV = CEREBRAL BLOOD VOLUME; CBF = CEREBRAL BLOOD FLOW (CBF); CBV_CORR = LEAKAGE CORRECTED CBV; CBF_CORR = LEAKAGE CORRECTED CBF (R REPRESENTS NORMALIZED WITH RESPECT TO NORMAL-APPEARING WM). BY SANKARALAYAM ET AL. (509-511)