Drug-device-field integration for tumor therapeutic interference with home-tailored nano-heterojunctions

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2024-12-21 DOI:10.1007/s42114-024-01184-y

Yandai Lin, Xueli Ren, Fengqi Xuan, Zhe Liu

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引用次数: 0

Abstract

Sonodynamic therapy has exhibited tremendous merits such as deep tissue penetration, minimal invasiveness, and neglectable side effects, but the strong O₂ dependence and complex tumor microenvironment limit the therapy efficiency. Herein, a type of BaTiO₃@MnO₂-based Z-scheme nano-heterojunction has been conjugated to doxorubicin-loaded carbon nanotubes to form functionalized hybrid nanocomposites for O₂-independent and TME-modulating combinational tumor therapy. The existences of BaTiO₃ and MnO₂ afford a built-in microelectric field which induces band tilting to effectively transfer electrons with a Z-scheme track, prolonged the electron–hole separation lifetime, and maintained strong redox potentials for hydrolysis and abundant reactive oxygen species generation. The in vivo experiments prove that nano-heterojunctions actively accumulate at the tumor after intravenous injection and demonstrate a glutathione-responsive behavior to impair tumor anti-oxidant and enhance ROS contents. It was also noted that the ultrasound-mediated treatment in association with nano-heterojunctions showed a superior O₂-independent tumor elimination (up to 90%) in company with dramatic recruitments of CD4⁺ and CD8⁺ T cells. Therefore, this study has validated the BaTiO₃@MnO₂-based Z-scheme nano-heterojunctions with tumor therapeutic interference in a drug-device-field integration manner and highlighted their promising utilities for modulating the tumor microenvironment and overcoming the O₂ dependence for an efficacious tumor therapy in live animals.

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.