Photoinduced Aromatization-Driven Deconstructive Fluorosulfonylation of Spiro Dihydroquinazolinones

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-11-30 DOI:10.1021/acs.joc.4c0230410.1021/acs.joc.4c02304

Wen-Peng Yang, Hong-Jie Miao, Gang Wang, Xiaoyu Yang, Xianjun Wang, Le Liu, Xin-Hua Duan* and Li-Na Guo*,

引用次数: 0

Abstract

A catalyst-free photoinduced deconstructive fluorosulfonylation cascade of spiro dihydroquinazolinones with DABSO and NFSI is reported. This protocol features mild reaction conditions, good yields and excellent functional group tolerance, providing a practical approach to the quinazolin-4(1H)-one-functionalized aliphatic sulfonyl fluorides. In addition, the ease of gram-scale synthesis and the versatility of the SuFEx exchange highlight the application potential of this protocol.

Abstract Image

查看原文本刊更多论文

光诱导芳构化驱动的螺旋二氢喹唑啉酮的解构氟磺化

报告了一种无催化剂光诱导的螺二氢喹唑啉酮与 DABSO 和 NFSI 的解构性氟磺酰化级联反应。该方案反应条件温和、产率高、官能团耐受性好，为喹唑啉-4(1H)-酮官能化脂肪族磺酰氟提供了一种实用的方法。此外，克级合成的简易性和 SuFEx 交换的多功能性也凸显了该方案的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.