Pneumococcal Septic Arthritis among Adults, France, 2010–2018

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-12-19 DOI:10.3201/eid3101.240321

Farida Hamdad, Nadim El Bayeh, Gabriel Auger, Olivia Peuchant, Frédéric Wallet, Raymond Ruimy, Florence Reibel, Christian Martin, Marie-Cécile Ploy, Frédéric Robin, Chrislène Laurens, Philippe Lanotte, Marie Kempf, Jennifer Tetu, Hélène Revillet, Isabelle Patry, Philippe Cailloux, Mélissa Azouaou, Emmanuelle Varon, Pierre Duhaut, Alain Lozniewski, Vincent Cattoir

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Abstract

Streptococcus pneumoniae infection is considered an uncommon cause of arthritis in adults. To determine the clinical and microbiological characteristics of pneumococcal septic arthritis, we retrospectively studied a large series of cases among adult patients during the 2010–2018 conjugate vaccine era in France. We identified 110 patients (56 women, 54 men; mean age 65 years), and cases included 82 native joint infections and 28 prosthetic joint infections. Most commonly affected were the knee (50/110) and hip (25/110). Concomitant pneumococcal infections were found in 37.2% (38/102) and bacteremia in 57.3% (55/96) of patients, and underlying conditions were noted for 81.4% (83/102). Mortality rate was 9.4% (8/85). The proportion of strains not susceptible to penicillin was 29.1% (32/110). Of the 55 serotyped strains, 31 (56.4%) were covered by standard pneumococcal vaccines; however, several nonvaccine serotypes (mainly 23B, 24F, and 15A) had emerged, for which susceptibility to β-lactams was low.

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成人肺炎球菌感染性关节炎，法国，2010-2018

肺炎链球菌感染被认为是成人关节炎的罕见病因。为了确定肺炎球菌感染性关节炎的临床和微生物学特征，我们回顾性研究了2010-2018年法国结合疫苗时代的大量成年患者病例。我们确定了110例患者(56例女性，54例男性；平均年龄65岁)，其中82例为天然关节感染，28例为假体关节感染。最常见的受累部位是膝关节（50/110）和髋关节（25/110）。合并肺炎球菌感染37.2%(38/102)，菌血症57.3%(55/96)，基础疾病81.4%（83/102）。死亡率为9.4%（8/85）。青霉素不敏感菌占29.1%（32/110）。55株血清型毒株中，31株（56.4%）被标准肺炎球菌疫苗覆盖；然而，出现了几种非疫苗血清型（主要是23B、24F和15A），它们对β-内酰胺的易感性较低。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.