Yuping Jiang, Yufeng Li, Kexuan Wang, Xiaomin Feng, Lu Han, Hai Yang
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引用次数: 0
Abstract
Phototherapy (PT) against melanoma continues to face significant great challenges with suitable photosensitizers, a hypoxic tumor microenvironment (TME), and aberrant tumor metabolic activities. Herein, we developed a MnO2-based bioresponsive nanoplatform (PIM NPs) that exerted multi-enzyme activities and synergized mitochondrial metabolism modulation for amplified PT and chemodynamic therapy (CDT) of melanoma. The PIM NPs were constructed by coating the MnO2 nanozymes shell onto mesoporous polydopamine nanoparticles (mPDA NPs) loaded with photosensitizer (ICG). The PIM NPs consumed H2O2 to generate O2 under acid TME, alleviating hypoxia to promote the photodynamic effect of ICG for producing toxic singlet oxygen (1O2). Meanwhile, the PIM NPs depleted glutathione (GSH) and triggered the Fenton-like reaction to destroy the antioxidant defense of the tumor cells. The photothermal property of mPDA NPs further enhanced the multi-enzyme activity and the effect of PT. Finally, the bioresponsive PIM NPs down-regulated glycolysis metabolism and oxidative phosphorylation, which disrupted the energy production and nutrient supply of tumor cells, causing the metabolic disorders of tumor cells. Both in vitro and in vivo results showed significant tumor inhibition, indicating that the PIM NPs achieved “All In One” strategy that combining tumor cell mitochondria metabolic regulation to amplify the effect of PT and CDT for melanoma, providing a promising integrated strategy against metabolic abnormalities of melanoma.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.