Carbon dot-based molecularly imprinted polymer fluorescent sensor for the detection of propranolol in plasma.

Abstract

Propranolol, a medication used to treat cardiovascular diseases, can be harmful when overdosed and hazardous to ecosystems if released into the environment. Here, a new molecularly imprinted fluorescent sensor was developed from carbon dots through a sol-gel method. Carbon dots served as both the fluorescent signal and the carrier, with propranolol as the template molecule and 3-aminopropyltriethoxysilane as the functional monomer to be grafted on carbon dots' surface. A novel detection method was established for the efficient, rapid, and cost-effective detection of propranolol in human plasma through quantitative analysis by using a fluorescence spectrophotometer and an ultraviolet spectrophotometer. Under the optimal conditions, the detection range of 0.5-4 mg L^-1, the detection limit of 0.092 mg L^-1, the imprinting factor of 2.42, and the detection response time of 2 min were achieved. The prepared carbon dot-based molecularly imprinted fluorescent sensor was proved to have a wide accurate linear range, low detection limit, and very short response time, and can detect lower analyte concentrations with higher detection accuracy.