Sustainable, Green, and Sensitive Spectrofluorimetric Approach for Pizotifen Maleate Detection in Tablets and Human Plasma via Photo-Induced Electron Transfer Inhibition

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2024-12-18 DOI:10.1002/bio.70059

Mahmoud A. Omar, Abobakr A. Mohamed, Yaser Alahmadi, Mohammed Almaghrabi, Rawan Bafail, Islam M. Mostafa

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Abstract

Pizotifen maleate (PZM) is an anti-migraine drug. Effective treatment requires accurate measurement of PZM levels in patients and constant medication concentrations in tablets. This paper presents a new spectrofluorimetric approach for detecting PZM in tablets and human blood plasma (spiked with PZM). The detection mechanism depends on the inhibition of the PZM molecule's photoinduced electron transfer (PET), resulting in a bright fluorescent intensity from PZM. Acetic acid (2.0 M) acidifies the reaction environment and causes PET inhibition. This approach detects PZM at concentrations ranging from 100 to 700 ng mL⁻¹. Furthermore, the approach has outstanding detection and quantification limits of 30.95 and 93.78 ng mL⁻¹, respectively. Also, the approach accurately measured PZM content homogeneity in each tablet and spiked human plasma samples without any interference. This new strategy represents a new and sensitive method for accurate PZM monitoring in different samples. Furthermore, the established fluorimetric method's greenness was evaluated.

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可持续、绿色、灵敏的光诱导电子转移抑制马来酸吡唑芬片剂和人血浆检测方法。

马来酸Pizotifen （PZM）是一种抗偏头痛的药物。有效的治疗需要精确测量患者体内的PZM水平和片剂中恒定的药物浓度。本文提出了一种新的分光光度法检测片剂和人血浆中PZM（加标PZM）的方法。检测机制依赖于抑制PZM分子的光致电子转移（PET），从而使PZM产生明亮的荧光强度。醋酸（2.0 M）使反应环境酸化，引起PET抑制。该方法检测浓度范围为100至700 ng mL-1的PZM。该方法具有良好的检测限和定量限，分别为30.95和93.78 ng mL-1。此外，该方法准确地测量了PZM含量均匀性在每片和加标人血浆样品没有任何干扰。该方法为不同样品中PZM的准确监测提供了一种灵敏的新方法。并对所建立的荧光法的绿色度进行了评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.