Triglyceride glucose index is associated with vertebral fracture in older adults: a longitudinal study.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2025-03-01 Epub Date: 2024-12-19 DOI:10.1007/s12020-024-04136-0

Zicheng Wei, Xifa Gao, Jiangchuan Wang, Yu Wang, Hongye Tang, Zhenyuan Ma, Jianhua Wang, Xiao Chen

{"title":"Triglyceride glucose index is associated with vertebral fracture in older adults: a longitudinal study.","authors":"Zicheng Wei, Xifa Gao, Jiangchuan Wang, Yu Wang, Hongye Tang, Zhenyuan Ma, Jianhua Wang, Xiao Chen","doi":"10.1007/s12020-024-04136-0","DOIUrl":null,"url":null,"abstract":"Purpose: Diabetes is a risk factor for bone fractures. However, the association between insulin resistance and the risk of fracture has not been well studied. In the present study, we explored the association of the triglyceride glucose index as a measure of insulin resistance with the risk of vertebral fracture in older adults.Methods: A total of 1995 subjects aged 50 years or older who underwent computed tomography (CT) for lung cancer screening from 2016-2021 were included in this study. They were followed until July 2023. Demographic information and laboratory test data were collected from the electronic medical system. Vertebral fractures were evaluated on the basis of sagittal CT images of the spine. The triglyceride glucose (TYG) index was calculated via the following equation: Ln [fasting glucose (mg/dl)×fasting triglyceride (mg/dl)/2]. The association between the TYG index and vertebral fracture incidence was evaluated via a multivariable Cox proportional hazards model.Results: Ninety-five cases of fracture were observed during the 60 months of follow-up. The incidence of fracture was lower for the fourth TYG index than for the first TYG index (3.26% vs. 6.00%, P = 0.04). The risk of vertebral fracture decreased with increasing TYG index (adjusted hazard ratio (aHR): 0.56, 95% confidence interval (CI): 0.35-0.90). Fracture risk was significantly lower in subjects with the highest TYG (the fourth quartile) than in those with the first quartile (aHR: 0.46, 95% CI: 0.22-0.96) according to the fully adjusted model. A similar association was observed in subjects without diabetes (aHR = 0.44, 95% CI: 0.21-0.95). Restricted cubic splines further revealed that the risk of vertebral fracture decreased with increasing TYG index.Conclusion: A greater TYG index was associated with a lower risk of vertebral fracture, independent of body mass index and bone mass.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1022-1030"},"PeriodicalIF":3.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-024-04136-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Diabetes is a risk factor for bone fractures. However, the association between insulin resistance and the risk of fracture has not been well studied. In the present study, we explored the association of the triglyceride glucose index as a measure of insulin resistance with the risk of vertebral fracture in older adults.

Methods: A total of 1995 subjects aged 50 years or older who underwent computed tomography (CT) for lung cancer screening from 2016-2021 were included in this study. They were followed until July 2023. Demographic information and laboratory test data were collected from the electronic medical system. Vertebral fractures were evaluated on the basis of sagittal CT images of the spine. The triglyceride glucose (TYG) index was calculated via the following equation: Ln [fasting glucose (mg/dl)×fasting triglyceride (mg/dl)/2]. The association between the TYG index and vertebral fracture incidence was evaluated via a multivariable Cox proportional hazards model.

Results: Ninety-five cases of fracture were observed during the 60 months of follow-up. The incidence of fracture was lower for the fourth TYG index than for the first TYG index (3.26% vs. 6.00%, P = 0.04). The risk of vertebral fracture decreased with increasing TYG index (adjusted hazard ratio (aHR): 0.56, 95% confidence interval (CI): 0.35-0.90). Fracture risk was significantly lower in subjects with the highest TYG (the fourth quartile) than in those with the first quartile (aHR: 0.46, 95% CI: 0.22-0.96) according to the fully adjusted model. A similar association was observed in subjects without diabetes (aHR = 0.44, 95% CI: 0.21-0.95). Restricted cubic splines further revealed that the risk of vertebral fracture decreased with increasing TYG index.

Conclusion: A greater TYG index was associated with a lower risk of vertebral fracture, independent of body mass index and bone mass.

查看原文本刊更多论文

甘油三酯葡萄糖指数与老年人椎体骨折相关：一项纵向研究。

目的：糖尿病是骨折的危险因素。然而，胰岛素抵抗与骨折风险之间的关系尚未得到很好的研究。在本研究中，我们探讨了甘油三酯葡萄糖指数作为胰岛素抵抗与老年人椎体骨折风险的关系。方法：本研究共纳入1995名年龄在50岁及以上的2016-2021年间接受CT肺癌筛查的受试者。他们被跟踪到2023年7月。从电子医疗系统中收集人口统计信息和实验室检测数据。根据脊柱矢状位CT图像评估椎体骨折。甘油三酯葡萄糖（TYG）指数通过以下公式计算：Ln[空腹葡萄糖（mg/dl）×fasting甘油三酯(mg/dl)/2]。TYG指数与椎体骨折发生率之间的关系通过多变量Cox比例风险模型进行评估。结果：随访60个月，共观察骨折95例。第四个TYG指数骨折发生率低于第一个TYG指数（3.26%比6.00%,P = 0.04）。椎体骨折的风险随着TYG指数的增加而降低（校正风险比（aHR）： 0.56, 95%可信区间（CI）： 0.35-0.90）。根据完全调整模型，TYG最高的受试者（第四个四分位数）骨折风险明显低于第一个四分位数（aHR: 0.46, 95% CI: 0.22-0.96）。在没有糖尿病的受试者中也观察到类似的关联（aHR = 0.44, 95% CI: 0.21-0.95）。限制三次样条进一步显示，椎体骨折的风险随TYG指数的增加而降低。结论：TYG指数越大，椎体骨折风险越低，与体重指数和骨量无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.