Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline.

IF 3.1 3区 医学 Q1 PEDIATRICS
Gina A Montealegre Sanchez, Lauren E Arrigoni, Alexandra B Yonts, Kevin B Rubenstein, James E Bost, Max T Wolff, Mallory C Barrix, W Patricia Bandettini, Bema Boateng, Dorothy I Bulas, Thomas R Burklow, Kayla P Carlyle, Marcus Chen, Sanchita Das, Robin L Dewar, Austin A Dixon, Maureen A Edu, Rachel L Falik, Monika L Geslak, Marcin Gierdalski, Ashraf S Harahsheh, Linda J Herbert, Jeroen Highbarger, Saira R Huq, Arthur Ko, Anastassios C Koumbourlis, Stephanie R Lacey, Andrew J Lipton, Maureen Monaghan, Anta S Ndour, Laura J Olivieri, Dinesh K Pillai, Catherine A Rehm, Craig A Sable, Vandana Sachdev, Audrey E Thurm, Uyen T Truong, Evrim B Turkbey, Eric Vilain, Shera Weyers, Jacob S White, Abigail A Williams, Jonathan Zember, C Jason Liang, Meghan Delaney, Mark L Batshaw, Luigi D Notarangelo, David L Wessel, Karyl Barron, Roberta L DeBiasi
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引用次数: 0

Abstract

Background: PECOS is an ongoing study aimed to characterize long-term outcomes following pediatric SARS-CoV-2 infection.

Methods: This is a cross-sectional analysis of infected and uninfected cohorts at baseline. Participants (0-21 years) with laboratory-confirmed SARS-CoV-2 infection were enrolled as infected. Uninfected were defined as individuals without history or laboratory evidence of SARS-CoV-2 infection. Outcome measures included demographics, medical history, review of symptoms, physical exam, cardiopulmonary evaluation and validated psychological and developmental surveys. Primary outcomes were cohort comparisons for abnormalities on all measures.

Results: 654 participants (541 infected, 113 uninfected) completed baseline visits by June 30, 2023. Infected participants were more likely to report constitutional (OR: 2.24), HEENT (OR: 3.74); respiratory (OR: 2.41), or gastrointestinal (OR: 2.58) symptoms. Infected had worse scores in domains of Pain, Fatigue, Global Health, Physical and Cognitive functioning, Mobility and Sleep disturbances when compared to uninfected controls using Patient Reported Outcomes. Cardiopulmonary findings were similar among cohorts.

Conclusions: The first report of this ongoing longitudinal study demonstrates that infected participants were more likely to report symptoms compared to uninfected controls, which may affect performance and quality of life of these individuals. Longitudinal data will increase understanding of long-term effects of SARS-CoV-2 infection in children.

Clinicaltrials: gov Identifier: NCT04830852 IMPACT: This study establishes a large, diverse, prospective, longitudinal, multi-center cohort of children with history of SARS-CoV-2 infection compared to an uninfected cohort to be followed for 3 years. Cross-sectional cohort analysis at study entry showed infected participants were more likely to report constitutional, respiratory, and GI symptoms compared to uninfected controls. Infected participants were more likely to have significantly worse parent-reported performance in 6 of 10 Patient Reported Outcome Measures domains. Continued study of this cohort will help identify clinical sequelae of COVID-19, characterize the immune response to SARS-CoV-2 infection, and identify potential genetic/immunologic factors associated with long-term outcomes.

儿童SARS-CoV-2长期结局研究(PECOS):基线横断面分析
背景:PECOS是一项正在进行的研究,旨在描述儿童SARS-CoV-2感染后的长期结局。方法:这是一项基线时感染和未感染队列的横断面分析。实验室确诊为SARS-CoV-2感染的参与者(0-21岁)作为感染者入组。未感染者定义为没有SARS-CoV-2感染史或实验室证据的个体。结果测量包括人口统计、病史、症状回顾、体格检查、心肺评估以及有效的心理和发育调查。主要结果是对所有指标的异常进行队列比较。结果:到2023年6月30日,654名参与者(541名感染者,113名未感染者)完成了基线就诊。感染的参与者更有可能报告体质(OR: 2.24), HEENT (OR: 3.74);呼吸道(OR: 2.41)或胃肠道(OR: 2.58)症状。根据患者报告结果,与未感染的对照组相比,感染者在疼痛、疲劳、整体健康、身体和认知功能、活动能力和睡眠障碍等方面的得分更差。各队列的心肺结果相似。结论:这项正在进行的纵向研究的第一份报告表明,与未感染的对照组相比,感染的参与者更有可能报告症状,这可能影响这些个体的表现和生活质量。纵向数据将增加对儿童感染SARS-CoV-2的长期影响的了解。影响:本研究建立了一个大型、多样化、前瞻性、纵向、多中心的SARS-CoV-2感染史儿童队列,与未感染队列进行了3年的随访。研究开始时的横断面队列分析显示,与未感染的对照组相比,感染的参与者更有可能报告体质、呼吸系统和胃肠道症状。受感染的参与者在10个患者报告的结果测量领域中的6个领域中更有可能有明显更差的父母报告表现。该队列的持续研究将有助于确定COVID-19的临床后遗症,表征对SARS-CoV-2感染的免疫反应,并确定与长期预后相关的潜在遗传/免疫因素。
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来源期刊
Pediatric Research
Pediatric Research 医学-小儿科
CiteScore
6.80
自引率
5.60%
发文量
473
审稿时长
3-8 weeks
期刊介绍: Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of children''s diseases and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies
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