Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults.

IF 1.8 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2025-04-08 DOI:10.1093/mr/roae113

Ambrish Singh, Alison Venn, Leigh Blizzard, Brooklyn J Fraser, Graeme Jones, John Burgess, Venkat Parameswaran, Lyn March, Flavia Cicuttini, Changhai Ding, Benny Antony

{"title":"Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults.","authors":"Ambrish Singh, Alison Venn, Leigh Blizzard, Brooklyn J Fraser, Graeme Jones, John Burgess, Venkat Parameswaran, Lyn March, Flavia Cicuttini, Changhai Ding, Benny Antony","doi":"10.1093/mr/roae113","DOIUrl":null,"url":null,"abstract":"Objectives: To examine associations between osteoarthritis (OA)-related biochemical markers and knee symptoms in middle-aged adults over 10-13 year follow-up.Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (2004-06) and follow-up at CDAH-3. Serum samples from baseline (n=156) and follow-up (n=167) were analyzed for cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA) using enzyme-linked immunosorbent assays. Knee symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale at follow-up. Zero-inflated Poisson regression models adjusted for age, sex, and body mass index were used for analysis.Results: Significant associations were observed between COMP, MMP-3, and HA with knee pain and WOMAC-total score at follow-up. Baseline MMP-3 [ratio of means (RoM): 1.013; 95% CI: 1.006, 1.020], cumulative COMP (baseline + follow-up) [RoM: 1.022; 95% CI: 1.011, 1.033], and increased HA levels over time [RoM: 1.014; 95% CI: 1.007, 1.020] were positively associated with knee pain after 10-13 years.Conclusion: Cumulative COMP, baseline MMP-3, and changes in HA were associated with knee pain over a a 10-13 year follow-up. These markers may help predict future knee symptoms in middle-aged adults.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"585-593"},"PeriodicalIF":1.8000,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Modern Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mr/roae113","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To examine associations between osteoarthritis (OA)-related biochemical markers and knee symptoms in middle-aged adults over 10-13 year follow-up.

Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (2004-06) and follow-up at CDAH-3. Serum samples from baseline (n=156) and follow-up (n=167) were analyzed for cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA) using enzyme-linked immunosorbent assays. Knee symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale at follow-up. Zero-inflated Poisson regression models adjusted for age, sex, and body mass index were used for analysis.

Results: Significant associations were observed between COMP, MMP-3, and HA with knee pain and WOMAC-total score at follow-up. Baseline MMP-3 [ratio of means (RoM): 1.013; 95% CI: 1.006, 1.020], cumulative COMP (baseline + follow-up) [RoM: 1.022; 95% CI: 1.011, 1.033], and increased HA levels over time [RoM: 1.014; 95% CI: 1.007, 1.020] were positively associated with knee pain after 10-13 years.

Conclusion: Cumulative COMP, baseline MMP-3, and changes in HA were associated with knee pain over a a 10-13 year follow-up. These markers may help predict future knee symptoms in middle-aged adults.

查看原文本刊更多论文

10-13年骨关节炎相关血清生化指标与中年人膝关节症状的关系

目的：描述随访10-13年的中年成人oa相关生化指标与膝关节症状之间的关系。方法：在儿童成人健康决定因素(CDAH)-1研究期间（2004- 2006年）收集血液样本，并在CDAH-3进行10-13年随访。使用非同位素酶联免疫吸附试验（ELISA）分析基线（n=156）和随访（n=167）的血清样本中三种oa相关生物标志物[软骨寡聚基质蛋白（COMP）、基质金属蛋白酶(MMP)-3和透明质酸（HA）]。随访时使用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）量表评估膝关节症状。采用单变量和多变量（调整年龄、性别和体重指数（BMI））零膨胀泊松（ZIP）回归模型进行分析。结果：在横断面多变量模型中，COMP[均值比（RoM）： 1.156；95%CI: 0.989, 1.324], MMP-3 [RoM: 1.013；95%CI: 1.001, 1.025], HA [RoM: 1.008；（95%CI: 1.002, 1.015）中年人膝关节疼痛和womac总分的差异。基线血清MMP-3 [RoM: 1.013；95%CI: 1.006, 1.020]，血清COMP总和[RoM: 1.022；95%CI: 1.011, 1.033]，血清HA升高[RoM: 1.014；（95%CI:1.007, 1.020）与10-13年后评估的膝关节疼痛显著正相关。结论：10-13年后评估的膝关节疼痛与青年期（基线）和中年期（随访）的累积COMP水平、青年期（基线）的MMP-3水平以及随访期间HA水平的变化呈正相关。这些在中年人中测量的生化指标可以进一步作为未来膝关节症状的预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions