Matthieu Rizk, Sarah Tebeka, Caroline Dubertret, Yann Le Strat
{"title":"Prevalence, correlates and comorbidity of irritability in adults with major depressive episode in the U.S. population (2012-2013).","authors":"Matthieu Rizk, Sarah Tebeka, Caroline Dubertret, Yann Le Strat","doi":"10.1016/j.jpsychires.2024.11.074","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Irritability has been documented in major depressive episodes (MDE) in children and adolescents. However, the prevalence of irritability in MDE and its clinical correlates remain unknown in adults.</p><p><strong>Method: </strong>We showed associations between the prevalence of irritability and its sociodemographic characteristics in a representative U.S. sample, along with the associations between irritability and other psychiatric disorders and its relationship with health-related quality of life. This cross-sectional study utilized a large national sample (n = 36,309) from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Face-to-face interviews were conducted to collect sociodemographic characteristics, structured diagnoses, and self-reported irritability.</p><p><strong>Results: </strong>The irritable MDE group (n = 4988) was compared to the non-irritable MDE group (n = 3065). The lifetime prevalence of irritability in MDE was estimated at 61.3%. Participants with irritable MDE were significantly more likely to report a lifetime history of psychiatric disorders (aOR = 1.96) than those with non-irritable MDE. Irritable MDE was also positively associated with severe MDE (aOR = 2.12). Participants with irritable MDE were more likely to report a lifetime history of suicide attempts (aOR = 1.15), substance use disorders (aOR = 1.54), mood disorders (aOR = 1.93), and anxiety disorders (aOR = 1.67). Participants with irritable MDE had lower levels of health-related quality of life than those with non-irritable MDE.</p><p><strong>Conclusions: </strong>The majority of adults with MDE exhibits irritability. Irritability is associated with severe characteristics and comorbidities, leading to a higher burden of depression.</p><p><strong>Significance: </strong>This study demonstrates a strong association between irritable MDE and psychiatric comorbidities, as well as a substantial burden of depression and related conditions. As a cross-sectional study using a representative sample of the U.S. population with highly reliable psychiatric diagnoses, our results are generalizable. Practitioners managing MDE should identify and treat these comorbidities.</p>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"517-522"},"PeriodicalIF":3.7000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jpsychires.2024.11.074","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Irritability has been documented in major depressive episodes (MDE) in children and adolescents. However, the prevalence of irritability in MDE and its clinical correlates remain unknown in adults.
Method: We showed associations between the prevalence of irritability and its sociodemographic characteristics in a representative U.S. sample, along with the associations between irritability and other psychiatric disorders and its relationship with health-related quality of life. This cross-sectional study utilized a large national sample (n = 36,309) from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Face-to-face interviews were conducted to collect sociodemographic characteristics, structured diagnoses, and self-reported irritability.
Results: The irritable MDE group (n = 4988) was compared to the non-irritable MDE group (n = 3065). The lifetime prevalence of irritability in MDE was estimated at 61.3%. Participants with irritable MDE were significantly more likely to report a lifetime history of psychiatric disorders (aOR = 1.96) than those with non-irritable MDE. Irritable MDE was also positively associated with severe MDE (aOR = 2.12). Participants with irritable MDE were more likely to report a lifetime history of suicide attempts (aOR = 1.15), substance use disorders (aOR = 1.54), mood disorders (aOR = 1.93), and anxiety disorders (aOR = 1.67). Participants with irritable MDE had lower levels of health-related quality of life than those with non-irritable MDE.
Conclusions: The majority of adults with MDE exhibits irritability. Irritability is associated with severe characteristics and comorbidities, leading to a higher burden of depression.
Significance: This study demonstrates a strong association between irritable MDE and psychiatric comorbidities, as well as a substantial burden of depression and related conditions. As a cross-sectional study using a representative sample of the U.S. population with highly reliable psychiatric diagnoses, our results are generalizable. Practitioners managing MDE should identify and treat these comorbidities.
期刊介绍:
Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research:
(1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors;
(2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology;
(3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;