Prevalence, correlates and comorbidity of irritability in adults with major depressive episode in the U.S. population (2012–2013)

IF 3.7 2区 医学 Q1 PSYCHIATRY
Matthieu Rizk , Sarah Tebeka , Caroline Dubertret , Yann Le Strat
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引用次数: 0

Abstract

Background

Irritability has been documented in major depressive episodes (MDE) in children and adolescents. However, the prevalence of irritability in MDE and its clinical correlates remain unknown in adults.

Method

We showed associations between the prevalence of irritability and its sociodemographic characteristics in a representative U.S. sample, along with the associations between irritability and other psychiatric disorders and its relationship with health-related quality of life. This cross-sectional study utilized a large national sample (n = 36,309) from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Face-to-face interviews were conducted to collect sociodemographic characteristics, structured diagnoses, and self-reported irritability.

Results

The irritable MDE group (n = 4988) was compared to the non-irritable MDE group (n = 3065). The lifetime prevalence of irritability in MDE was estimated at 61.3%. Participants with irritable MDE were significantly more likely to report a lifetime history of psychiatric disorders (aOR = 1.96) than those with non-irritable MDE. Irritable MDE was also positively associated with severe MDE (aOR = 2.12). Participants with irritable MDE were more likely to report a lifetime history of suicide attempts (aOR = 1.15), substance use disorders (aOR = 1.54), mood disorders (aOR = 1.93), and anxiety disorders (aOR = 1.67). Participants with irritable MDE had lower levels of health-related quality of life than those with non-irritable MDE.

Conclusions

The majority of adults with MDE exhibits irritability. Irritability is associated with severe characteristics and comorbidities, leading to a higher burden of depression.

Significance

This study demonstrates a strong association between irritable MDE and psychiatric comorbidities, as well as a substantial burden of depression and related conditions. As a cross-sectional study using a representative sample of the U.S. population with highly reliable psychiatric diagnoses, our results are generalizable. Practitioners managing MDE should identify and treat these comorbidities.
2012-2013年美国人群中重度抑郁发作的成人易怒的患病率、相关性和共病
背景:易怒在儿童和青少年重度抑郁发作(MDE)中已被证实。然而,在成人中,MDE中易怒的患病率及其临床相关性仍然未知。方法:我们在一个具有代表性的美国样本中显示了易怒的患病率与其社会人口学特征之间的关联,以及易怒与其他精神疾病之间的关联及其与健康相关的生活质量的关系。这项横断面研究利用了来自全国酒精及相关疾病流行病学调查iii的大型全国样本(n = 36,309)。进行面对面访谈以收集社会人口学特征、结构化诊断和自我报告的易怒。结果:将易激MDE组(n = 4988)与非易激MDE组(n = 3065)进行比较。MDE患者的终生易怒患病率估计为61.3%。易激惹性MDE的参与者比非易激惹性MDE的参与者更有可能报告终生精神疾病史(aOR = 1.96)。激惹性MDE与重度MDE呈正相关(aOR = 2.12)。易激惹性MDE的参与者更有可能报告有自杀企图(aOR = 1.15)、物质使用障碍(aOR = 1.54)、情绪障碍(aOR = 1.93)和焦虑症(aOR = 1.67)的终生史。与非激惹性MDE患者相比,激惹性MDE患者的健康相关生活质量水平较低。结论:大多数MDE患者表现为易怒。易怒与严重的特征和合并症有关,导致更高的抑郁负担。意义:本研究表明,激惹性MDE与精神合并症,以及抑郁症和相关疾病的沉重负担之间存在很强的关联。作为一项横断面研究,使用具有高度可靠的精神病诊断的美国人口的代表性样本,我们的结果是可推广的。管理MDE的从业者应该识别和治疗这些合并症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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