Optimizing topical nasal steroid application in adenoid hypertrophy: A computational fluid dynamics (CFD) analysis.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2024-12-14 DOI:10.1016/j.ijporl.2024.112205

Bigyan Raj Gyawali, Ashutosh Kashyap, Sanju Thapa, Darshan Chaulagain, Suyogya Shakya, Niraj Kumar Kushwaha

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引用次数: 0

Abstract

Introduction: Intranasal steroids are effective in managing adenoid hypertrophy in children, but the evidence regarding technique of use for optimal results is lacking.

Methods: CFD analysis, with discrete phase modelling was done to simulate nasal spray in nasal cavity and drug delivery in the region of adenoids. The findings were validated using a 3D model designed from CT scan of the same region.

Results: Our study shows that the maximum spray deposition in the adenoid region is with injection angle of 30° with the concentration value of 14 kg/m³.

Discussion: Nasal steroids have been found to be quite effective in symptoms reduction in children with adenoid hypertrophy. The current guidelines for technique of application are similar to that which has been validated for nasal pathologies. But the studies analyzing optimum drug delivery to the adenoids with variations in technique of application are lacking. This is the research gap we have tried to fill with our study.

Conclusion: The application of nasal steroids with nozzle inclined at 30° with respect to the floor of nose ensures maximum drug delivery to the adenoids and is likely to improve the efficacy of this treatment.

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.