Altered gray matter structural covariance networks in young adults with obesity.

Abstract

Background: Overwhelming evidence showed that obesity was associated with abnormal brain functional networks. However, the changes of structural covariance networks (SCNs) based on cortical thickness (CT) and cortical surface area (CSA) in obesity is still unclear.

Methods: In this study, 243 young adults with obesity and matched 243 lean individuals were enrolled from the Human Connectome Project Release S1200 dataset. All participants underwent magnetic resonance imaging scans following clinical and neuropsychological assessments. SCNs matrices were constructed by Brain Connectivity Toolbox based on both CT and CSA. Nonparametric permutation tests were adopted to examine group differences of these matrices.

Results: Young adults with obesity exhibited lower CSA of left entorhinal cortex, but higher CT of both left rostral anterior cingulate cortex and right superior parietal lobule, as well as lower CT of left temporal pole. While in terms of global network measures, there were no significant group differences; in terms of nodal network measures, young adults with obesity exhibited alterations in widespread brain regions including left posterior cingulate cortex, bilateral superior frontal gyrus, left entorhinal cortex and right insula.

Conclusions: Young adults with obesity exhibited abnormal nodal network measures in widespread brain regions involved in default mode network, central executive network and salience network. These findings indicate the adverse effects of obesity on young adults might be associated with the altered triple network.