High prevalence of hepatitis C virus infection among adolescents and young adults attending HIV and sexual health clinics.

IF 1.4 4区医学 Q4 IMMUNOLOGY

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI:10.1177/09564624241302231

Krisanee Pansue, Pathariya Promsena, Wipaporn Natalie Songtaweesin, Juthamanee Moonwong, Juliet Ryan, Surinda Kawichai, Kessarin Thanapirom, Thanyawee Puthanakit

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引用次数: 0

Abstract

Background: The prevalence of hepatitis C virus (HCV) infection among Thai adults is 0.5%-1.0%. This study aims to determine the prevalence of HCV infection among adolescents and young adults (AYA) accessing HIV/sexual health clinics.

Methods: A cross-sectional study was conducted among AYA aged 15-24 years attending HIV/sexual health clinics in Bangkok, Thailand. The HCV infection prevalence, defined by anti-HCV antibody positivity using rapid diagnostic tests (SD BIOSENSOR, Korea), were reported with proportions and a 95% confidence interval (CI). Multivariate logistic regression was performed to identify factors associated with HCV infection.

Results: From March to August 2023, 300 AYAs with a median age of 21 (interquartile range 20-23) years were enrolled into the study. One-third (29.7%) were people living with HIV (PLHIV). The overall prevalence of HCV infection was 2.7% (95%CI 1.2-5.2). Prevalence was higher among PLHIV (5.6%) compared to AYA without HIV (1.4%) (p-value 0.053). The factor most significantly associated with HCV infection was people who used drugs (adjusted odds ratio 15.3, 95% CI 2.9-82.0, p-value 0.001).

Conclusions: History of drug use was associated with the highest HCV infection prevalence. PLHIV had a trend of higher prevalence. HCV screening in HIV/sexual health clinics is recommended for early detection, treatment, and transmission reduction.

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在参加艾滋病毒和性健康诊所的青少年和年轻人中，丙型肝炎病毒感染率很高。

背景：泰国成人丙型肝炎病毒（HCV）感染率为0.5%-1.0%。本研究旨在确定前往艾滋病毒/性健康诊所的青少年和年轻人（AYA）中丙型肝炎病毒感染的流行程度。方法：对泰国曼谷艾滋病毒/性健康诊所15-24岁的AYA进行横断面研究。使用快速诊断测试（SD BIOSENSOR，韩国）以抗HCV抗体阳性定义的HCV感染流行率，报告了比例和95%置信区间（CI）。进行多因素logistic回归以确定与HCV感染相关的因素。结果：从2023年3月至8月，300名年龄中位数为21岁（四分位数间距20-23岁）的AYAs入组研究。三分之一（29.7%）是艾滋病毒感染者。HCV感染的总患病率为2.7% （95%CI 1.2-5.2）。PLHIV的患病率（5.6%）高于未感染HIV的AYA (1.4%) （p值0.053）。与HCV感染最显著相关的因素是使用药物的人（校正优势比15.3,95% CI 2.9-82.0， p值0.001）。结论：药物使用史与HCV感染率最高相关。PLHIV呈上升趋势。建议在艾滋病毒/性健康诊所进行HCV筛查，以便及早发现、治疗和减少传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of STD & AIDS 医学-传染病学

CiteScore

2.60

自引率

7.10%

发文量

144

审稿时长

3-6 weeks

期刊介绍： The International Journal of STD & AIDS provides a clinically oriented forum for investigating and treating sexually transmissible infections, HIV and AIDS. Publishing original research and practical papers, the journal contains in-depth review articles, short papers, case reports, audit reports, CPD papers and a lively correspondence column. This journal is a member of the Committee on Publication Ethics (COPE).