Magnetic resonance imaging of brain structural and functional changes in cognitive impairment associated with Parkinson's disease.

IF 4.1 2区 医学 Q2 GERIATRICS & GERONTOLOGY
Frontiers in Aging Neuroscience Pub Date : 2024-12-04 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1494385
Danna Cao, Jinhuan Yue, Zeyi Wei, Dong-Hong Huang, Xuchen Sun, Ke-Xuan Liu, Peng Wang, Fan Jiang, Xiaoling Li, Qinhong Zhang
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引用次数: 0

Abstract

Cognitive impairment is a critical non-motor symptom of Parkinson's Disease (PD) that profoundly affects patients' quality of life. Magnetic Resonance Imaging (MRI) has emerged as a valuable tool for investigating the structural and functional brain changes associated with cognitive impairment in PD (PD-CI). MRI techniques enable the precise identification and monitoring of the onset and progression of cognitive deficits in PD. This review synthesizes recent literature on the use of MRI-based techniques, including voxel-based morphometry, diffusion tensor imaging, and functional MRI, in the study of PD-CI. By examining these imaging modalities, the article aims to elucidate the patterns of brain structural and functional alterations in PD-CI, offering critical insights that can inform clinical management and therapeutic strategies. In particular, this review provides a novel synthesis of recent advancements in understanding how specific MRI metrics, such as amplitude of low-frequency fluctuations, regional homogeneity, and functional connectivity, contribute to early detection and personalized treatment approaches for PD-CI. The integration of findings from these studies enhances our understanding of the neural mechanisms underlying cognitive impairment in PD and highlights the potential of MRI as a supportive tool in the clinical assessment and treatment of PD-CI.

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来源期刊
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES
CiteScore
6.30
自引率
8.30%
发文量
1426
期刊介绍: Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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