Association between plasma trimethylamine N-oxide and cerebral white matter hyperintensity: a cross-sectional study.

IF 4.1 2区 医学 Q2 GERIATRICS & GERONTOLOGY
Frontiers in Aging Neuroscience Pub Date : 2024-12-04 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1498502
Xiaotan Ji, Xudong Zhang, Jie Zhang, Shenna Niu, Hui Cong Xiao, Hong Chen, Chuanqiang Qu
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引用次数: 0

Abstract

Background: Cerebral white matter hyperintensity (WMH) is a pivotal imaging feature of cerebral small vessel disease (CSVD), closely correlated with an elevated risk of ischemic stroke (IS). Trimethylamine N-oxide (TMAO), a metabolite of gut microbiota, is increasingly associated with IS and atherosclerosis. However, the intricate relationship between TMAO and WMH remains ambiguous. This study aimed to study the connection between plasma TMAO and WMH. Furthermore, it assessed the potential of TMAO as a risk evaluation instrument for WMH.

Methods: In this cross-sectional study, we categorized WMH into periventricular WMH (P-WMH) and deep WMH (D-WMH), based on its locations. The severity of WMH was assessed and grouped according to the Fazekas scale. Plasma TMAO levels were quantitatively determined. We established the correlation between plasma TMAO levels and WMH severity using a Logistic regression model. Additionally, we employed ROC curves to evaluate the diagnostic efficacy of plasma TMAO concentration in distinguishing the severity of WMH.

Results: A higher plasma TMAO tertile was significantly linked to a higher Fazekas score, encompassing the overall score, P-WMH score, and D-WMH score (p < 0.001). A logical regression analysis revealed that plasma TMAO levels were independently associated with overall moderate and severe WMH, compared to overall non-mild WMH, in the unadjusted model (OR = 1.373, 95%CI 1.183-1.594 for moderate; OR = 1.384, 95%CI 1.192-1.607 for severe), the adjusted model a (OR = 1.436, 95%CI 1.214-1.669 for moderate; OR = 1.446, 95%CI 1.222-1.711 for severe) and the adjusted model b (OR = 1.490, 95%CI 1.234-1.800 for moderate; OR = 1.494, 95%CI 1.237-1.805 for severe). The analysis also showed an independent correlation between plasma TMAO levels and WMH severity, irrespective of the unadjusted model, adjusted model a, or adjusted model b, when considering P-WMH and D-WMH severity. The ROC indicated that, in overall WMH and P-WMH, the area under curve (AUC) for non-mild and severe WMH were both>0.5, while the AUC for moderate WMH was<0.5. In contrast, in D-WMH, the AUC for non-mild, moderate, and severe WMH were all>0.5.

Conclusion: Plasma TMAO levels exhibited a significant correlation with both overall and region-specific WMH severity. Furthermore, the plasma TMAO levels displayed robust predictive capability for D-WMH.

血浆三甲胺n -氧化物与脑白质高强度之间的关系:一项横断面研究。
背景:脑白质高信号(WMH)是脑小血管疾病(CSVD)的关键影像学特征,与缺血性卒中(is)风险升高密切相关。三甲胺n -氧化物(TMAO)是肠道微生物群的代谢物,与is和动脉粥样硬化的关系越来越密切。然而,TMAO和WMH之间的复杂关系仍然不明确。本研究旨在探讨血浆TMAO与WMH之间的关系。此外,它还评估了TMAO作为WMH风险评估工具的潜力。方法:在横断面研究中,我们根据其位置将WMH分为心室周围WMH (P-WMH)和深部WMH (D-WMH)。根据Fazekas量表对WMH的严重程度进行评估和分组。定量测定血浆TMAO水平。我们使用Logistic回归模型建立了血浆TMAO水平与WMH严重程度之间的相关性。此外,我们采用ROC曲线来评估血浆TMAO浓度在区分WMH严重程度方面的诊断效果。结果:较高的血浆TMAO指数与较高的Fazekas评分显著相关,包括总分、p -WMH评分和D-WMH评分(p 0.5),而中度WMH的AUC为0.5。结论:血浆TMAO水平与整体和区域特异性WMH严重程度均有显著相关性。此外,血浆TMAO水平对D-WMH具有强大的预测能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES
CiteScore
6.30
自引率
8.30%
发文量
1426
期刊介绍: Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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