Does microperimetry have a role in monitoring visual function in patients with Behçet uveitis?

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2024-12-18 DOI:10.1186/s12886-024-03805-y

Mehmet Fatih Kağan Değirmenci, F Nilüfer Yalçındağ

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引用次数: 0

Abstract

Background: To evaluate the change in time in visual acuity, central macular thickness (CMT), and microperimetry (MP) findings in Behçet uveitis (BU) patients who were in remission with maintenance therapy.

Methods: This single center, retrospective, observational cohort study included twenty-five eyes of 25 patients with BU who were in remission during maintenance therapy. Best corrected visual acuity (BCVA), CMT, macular integrity index, average threshold, and fixation stabilities (P1 and P2) evaluated at six-month intervals were recorded. The changes in time were statistically analyzed. Paired samples t-test was used for normally distributed data and Wilcoxon rank test was performed for non-normally distributed data.

Results: The mean BCVA and CMT showed no significant changes after six months. Although the mean macular integrity index decreased and the mean fixation stabilities increased after six months, these findings were not statistically significant. The mean average threshold was 16.8 dB at baseline and it increased significantly to 19.3 dB in the sixth month (p < 0.001).

Conclusions: The results of our study suggest that although visual acuity and CMT showed no change in patients with Behçet uveitis receiving maintenance therapy, MP could detect an improvement in macular function.

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显微镜检查是否对behaperet葡萄膜炎患者的视觉功能有监测作用？

背景：评估behet葡萄膜炎（BU）患者在维持治疗缓解期的视力、中央黄斑厚度（CMT）和显微视力（MP）的时间变化。方法：这项单中心、回顾性、观察性队列研究包括25例在维持治疗期间缓解的布鲁里溃疡患者的25只眼睛。记录最佳矫正视力（BCVA）、CMT、黄斑完整性指数、平均阈值和固定稳定性（P1和P2）每隔6个月评估一次。对时间变化进行统计学分析。正态分布资料采用配对样本t检验，非正态分布资料采用Wilcoxon秩次检验。结果：术后6个月平均BCVA和CMT无明显变化。虽然6个月后平均黄斑完整性指数下降，平均固定稳定性增加，但这些结果没有统计学意义。平均阈值在基线时为16.8 dB，在第六个月显著增加到19.3 dB (p)。结论：我们的研究结果表明，虽然接受维持治疗的behet葡萄膜炎患者的视力和CMT没有变化，但MP可以检测黄斑功能的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.