Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series.

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Paul Bastelica, Romain Magny, Joël Poupon, Bertrand Sonigo, Tristan Aubert, Françoise Brignole-Baudouin, Juliette Buffault, Christophe Baudouin, Antoine Labbé
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Abstract

Background: The EyeCee® ONE intraocular lens (Nidek, Gamagori, Japan) has been withdrawn from the market due to a high number of reports of severe ocular hypertension (OHT) following phacoemulsification with implantation of this intraocular lens (IOL). In this case series, we report the results of a toxicological analysis and the surgical management of five patients with severe OHT following the implantation of defective EyeCee® ONE IOLs during cataract surgery.

Cases presentation: Five patients developed early, severe OHT refractory to maximal medical therapy following uneventful phacoemulsification (PCE) cataract surgery with implantation of an EyeCee® ONE IOL from a defective lot. Glaucoma filtering surgeries were required to control intraocular pressure (IOP). Toxicological analyses were carried out on the aqueous humor of one patient. IOP levels were monitored during postoperative follow-up, but three patients required postoperative adjustments (reintroduction of IOP-lowering therapy, goniopuncture or needling) in order to maintain IOP at satisfactory levels. Toxicological analysis revealed a high concentration of silicon in the aqueous humor of the patient from whom the sample was obtained.

Conclusions: These cases of OHT following cataract surgery with a defective IOL were of early onset severe, all requiring filtering surgery. The exact mechanism of this OHT has not been determined, but we did find high concentrations of silicon in the aqueous humor of one of these patients. Patients who received EyeCee® ONE IOLs during the same period of time should have their IOP and optic nerve monitored to detect any potential OHT or glaucoma that might appear over time.

eyeecee®ONE人工晶状体植入术后高眼压的处理和毒理学分析:一个病例系列。
背景:EyeCee®ONE人工晶状体(Nidek, Gamagori, Japan)已经退出市场,原因是大量报道称白内障乳化植入术后出现严重眼压升高(OHT)。在本病例系列中,我们报告了5例在白内障手术中植入有缺陷的EyeCee®ONE iol后出现严重OHT的患者的毒理学分析和手术处理结果。病例介绍:5例患者在顺利进行白内障超声乳化手术(PCE)并植入缺陷批次的EyeCee®ONE人工晶状体后发生早期严重OHT,对最大药物治疗难治性。青光眼滤过手术控制眼压(IOP)。对1例患者房水进行了毒理学分析。术后随访期间监测IOP水平,但有3例患者需要术后调整(重新引入降眼压治疗、眼腺穿刺或针刺)以维持眼压在令人满意的水平。毒理学分析显示,在获得样品的病人的房水中有高浓度的硅。结论:这些白内障手术合并人工晶状体缺陷后发生OHT的病例均为早发性严重病例,均需行滤过手术。这种OHT的确切机制尚未确定,但我们确实在其中一名患者的房水中发现了高浓度的硅。在同一时间内接受EyeCee®ONE iol的患者应监测他们的IOP和视神经,以检测可能出现的任何潜在的OHT或青光眼。
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来源期刊
BMC Ophthalmology
BMC Ophthalmology OPHTHALMOLOGY-
CiteScore
3.40
自引率
5.00%
发文量
441
审稿时长
6-12 weeks
期刊介绍: BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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