Oral self-management of palbociclib using mobile technology: Findings from a nurse-led randomized controlled trial

IF 2.4 3区 医学 Q1 NURSING
AnnMarie Mazzella-Ebstein , Margaret Barton-Burke , Venice Anthony , Charlie White , Zhigang Zhang , Andrea Smith , Mark Robson
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Abstract

Objective

Test the feasibility and effectiveness of a text message reminder intervention for the self-management of oral anticancer medication in patients with metastatic breast cancer.

Methods

Forty-three females initiating treatment with palbociclib participated in a two-armed prospective randomized clinical trial. Participants were randomized into the control (n = 21) and intervention groups (n = 22) from January 2020 to January 2023. Survey responses were collected at three-time points; (1) at consent, (2) end of treatment cycles, and (3) at a follow-up clinic visit. Surveys included a demographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, post-study assessment, and the R-15 Participant Satisfaction Questionnaire. Nurse providers completed the Adaptation of Stamps Nurse Workload questionnaire.

Results

The COVID-19 pandemic and regulatory decisions supporting other CDK4/6 medications negatively influence recruitment; thus, a small sample for each arm only detected large differences between the two arms regarding effectiveness. Feasibility analysis was not conducted due to insufficient data, but the participants frequently used their smartphones for text messaging. Although the survey data were limited, participants provided anecdotal information supporting the use of text messaging as a positive method to remind them to take their medication, have their labs drawn, and attend MD visits. Participants would have liked text messages at the exact time they took their medications as a simple reminder.

Conclusions

Given the importance of cancer treatments and the difficulties patients experience during these treatments, text messages using smartphones can actively improve patients' engagement and their ability to manage their treatment regimens.

Trial registration

ClinicalTrials.gov; ID: NCT04216576.
使用移动技术的帕博西尼口服自我管理:来自护士主导的随机对照试验的结果。
目的:探讨短信提醒干预对转移性乳腺癌患者口服抗癌药物自我管理的可行性和有效性。方法:43名开始接受帕博西尼治疗的女性参加了一项双臂前瞻性随机临床试验。从2020年1月至2023年1月,参与者被随机分为对照组(n = 21)和干预组(n = 22)。在三个时间点收集调查回复;(1)同意时,(2)治疗周期结束时,(3)门诊随访时。调查包括人口调查问卷、欧洲癌症研究和治疗组织生活质量调查问卷、研究后评估和R-15参与者满意度调查问卷。护士服务提供者完成了邮票护士工作量适应问卷。结果:COVID-19大流行和支持其他CDK4/6药物的监管决策对招募产生负面影响;因此,每个组的小样本只检测到两个组在有效性方面的巨大差异。由于数据不足,没有进行可行性分析,但参与者经常使用智能手机发短信。尽管调查数据有限,但参与者提供的轶事信息支持使用短信作为一种积极的方法来提醒他们吃药、做化验和去看医生。参与者希望在服药的确切时间收到短信,作为一种简单的提醒。结论:考虑到癌症治疗的重要性和患者在治疗过程中遇到的困难,使用智能手机发送短信可以积极提高患者的参与度和管理治疗方案的能力。试验注册:ClinicalTrials.gov;ID: NCT04216576。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.80
自引率
11.10%
发文量
136
审稿时长
31 days
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