Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study.

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2024-12-18 DOI:10.1186/s12888-024-06350-6

Qinwei Liu, Wenjing Liao, Li Yang, Longfei Cao, Ningning Liu, Yongxue Gu, Shaohua Wang, Xiaobin Xu, Huafen Wang

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Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with different subtypes of pathogenesis. Insufficient research on the subtypes of ADHD has limited the effectiveness of therapeutic methods.

Methods: This study used resting-state functional near-infrared spectroscopy (fNIRS) to record hemodynamic signals in 34 children with ADHD-combined subtype (ADHD-C), 52 children with ADHD-inattentive subtype (ADHD-I), and 24 healthy controls (HCs). The amplitude of low-frequency fluctuation (ALFF) and the functional connectivity (FC) analysis were conducted for all subjects.

Results: Compared with HCs, the ADHD group exhibited significantly increased ALFF and decreased FC. The ADHD-C group showed significantly higher ALFF in partial brain regions and significantly lower FC between multiple brain regions than participants with ADHD-I. The male group displayed a significant increase in ALFF in some brain regions, while no significant difference was found in FC when compared to the female group.

Conclusions: This study provides evidence to support the subtype classification of ADHD-I and ADHD-C, and the combined analysis of ALFF and FC has the potential to be a promising biomarker for the diagnosis of ADHD.

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不同亚型ADHD儿童低频波动异常幅度和功能连通性：静息状态fNIRS研究

背景：注意缺陷/多动障碍（ADHD）是一种具有不同亚型发病机制的神经发育障碍。对ADHD亚型的研究不足限制了治疗方法的有效性。方法：采用静息状态功能近红外光谱（fNIRS）记录34例adhd合并亚型（ADHD-C）患儿、52例adhd不注意亚型（ADHD-I）患儿和24例健康对照（hc）患儿的血流动力学信号。对所有受试者进行低频波动幅度（ALFF）和功能连通性（FC）分析。结果：与hc比较，ADHD组ALFF显著升高，FC显著降低。ADHD-C组在部分脑区的ALFF显著高于ADHD-I组，在多个脑区的FC显著低于ADHD-I组。男性组在部分脑区ALFF显著增加，而FC与女性组相比无显著差异。结论：本研究为ADHD- i和ADHD- c亚型分类提供了证据支持，ALFF和FC的联合分析有可能成为ADHD诊断的一种有前景的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.