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Electrochemiluminescence immunosensor using a lanthanum-based metal-organic framework as signal probe and Cu2MoS4 as a co-reaction promoter for the sensitive detection of anti-Müllerian hormone

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2024-12-16 DOI:10.1016/j.talanta.2024.127406

Jing Li, Shenglan Hu, Lingling Zheng, Lixin Xu, Yusheng Wu, Biyang Deng

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引用次数: 0

Abstract

In this study, we used meso-tetra (4-carboxyphenyl) porphyrin (TCPP) as an organic ligand to modify a lanthanide-based metal-organic framework as an electrochemiluminescence (ECL) platform to sensitively detect anti-Müllerian hormone (AMH). La-MOF amplified the ECL signal by suppressing the aggregation-caused quenching created by TCPP self-aggregation. Utilizing the reversible cycling of the mixed-valence transition metal ion (Cu⁺/Cu²⁺ and Mo⁴⁺/Mo⁶⁺) and the electrical conductivity of Cu₂MoS₄ and silver nanoparticle (AgNP), Cu₂MoS₄–AgNP as a dual co-reaction promoter constantly generated sulfate radical anions (SO₄^•–) and thus amplified the ECL signal. Based on this strategy, we built a sandwich-type ECL immunosensor for the sensitive detection of AMH with a linear range of 1 × 10⁻⁴ to 50 ng/mL and a limit of detection of 24 fg/mL. This study provides a novel approach for the sensitive and selective detection of AMH, demonstrating its high potential and practical value for the sensitive detection of AMH.

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以镧基金属有机骨架为信号探针，以Cu2MoS4为共反应启动子的电化学发光免疫传感器用于抗勒氏菌激素的灵敏检测。

本研究以中四（4-羧基苯基）卟啉（TCPP）为有机配体修饰镧系金属-有机骨架，作为电化学发光（ECL）平台，灵敏检测抗勒氏菌激素（AMH）。La-MOF通过抑制TCPP自聚集引起的猝灭来放大ECL信号。利用混合价过渡金属离子（Cu+/Cu2+和Mo4+/Mo6+）的可逆循环以及Cu2MoS4和银纳米粒子（AgNP）的导电性，Cu2MoS4-AgNP作为双共反应促进剂不断生成硫酸盐自由基阴离子（SO4•-），从而放大ECL信号。基于该策略，我们构建了一种三明治型ECL免疫传感器，用于AMH的灵敏检测，线性范围为1 × 10-4 ~ 50 ng/mL，检测限为24 fg/mL。本研究为AMH的灵敏和选择性检测提供了一种新的方法，在AMH的灵敏检测中具有很高的潜力和实用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.

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thioacetamide

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sodium molybdate dihydrate

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polyvinylpyrrolidone

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5,5-dimethyl-1-pyrroline N-oxide

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gold chloride trihydrate

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meso-tetra (4-carboxyphenyl) porphyrin

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gold chloride trihydrate (HAuCl4·3H2O)

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di-sodium hydrogen phosphate dodecahydrate (Na2HPO4·12H2O)

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