Hydrogel-antimicrobial peptide association: A novel and promising strategy to combat resistant infections

IF 5.4 2区 医学 Q1 BIOPHYSICS
Marcelo Guerrero , David Filho , Nicolás Ayala A , Diana Rafael , Fernanda Andrade , Adolfo Marican , Sekar Vijayakumar , Esteban F. Durán-Lara
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引用次数: 0

Abstract

Infections from multi-drug resistant bacteria (MDRB) have raised a worldwide concern, with projections indicating that fatalities from these infections could surpass those from cancer by 2050. This troubling trend is influenced by several factors, including the scarcity of new antibiotics to tackle challenging infections, the prohibitive costs of last-resort antibiotics, the inappropriate use of antimicrobial agents in agriculture and aquaculture, and the over-prescription of antibiotics in community settings. One promising alternative treatment is the application of antimicrobial peptides (AMPs) against MDRB. Hydrogels can facilitate the delivery of these antimicrobials, enhancing their biocompatibility and bioavailability. The Peptide-Hydrogel Association (PHA) capitalizes on the distinct properties of both peptides and hydrogels, resulting in multifunctional systems suitable for various antibacterial purposes. Multiple strategies can be employed to develop a PHA, including peptide-based hydrogels, hydrogels infused with peptides, and hydrogels modified with peptide functionalities. The research examined in this review showcases the strong effectiveness of these systems against MDRB and underscores their potential in creating multifunctional and multi-responsive solutions for various infection scenarios. The high efficacy of PHAs represents a promising and innovative therapeutic strategy in combating infections caused by MDRB.
水凝胶-抗菌肽关联:对抗耐药感染的一种新的有前途的策略。
耐多药细菌(MDRB)的感染引起了全世界的关注,预测表明,到2050年,这些感染的死亡人数可能超过癌症。这一令人不安的趋势受到若干因素的影响,包括用于应对具有挑战性的感染的新抗生素短缺、最后使用抗生素的成本过高、农业和水产养殖中不适当使用抗菌药物以及社区环境中抗生素的过度处方。一种有希望的替代治疗方法是应用抗菌肽(AMPs)治疗MDRB。水凝胶可以促进这些抗菌剂的递送,提高它们的生物相容性和生物利用度。肽-水凝胶协会(PHA)利用肽和水凝胶的不同性质,产生适合各种抗菌目的的多功能系统。可以采用多种策略来开发PHA,包括基于肽的水凝胶,注入肽的水凝胶和肽功能修饰的水凝胶。本综述的研究展示了这些系统对抗MDRB的强大有效性,并强调了它们在为各种感染情景创建多功能和多反应性解决方案方面的潜力。pha的高疗效代表了对抗MDRB引起的感染的一种有前途和创新的治疗策略。
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来源期刊
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces 生物-材料科学:生物材料
CiteScore
11.10
自引率
3.40%
发文量
730
审稿时长
42 days
期刊介绍: Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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