Research Review: A review of the past decade of family and genomic studies on adolescent mental health.

IF 6.5 1区 医学 Q1 PSYCHIATRY
Geneviève Morneau-Vaillancourt, Elisavet Palaiologou, Tinca J C Polderman, Thalia C Eley
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引用次数: 0

Abstract

Background: Mental health problems and traits capturing psychopathology are common and often begin during adolescence. Decades of twin studies indicate that genetic factors explain around 50% of individual differences in adolescent psychopathology. In recent years, significant advances, particularly in genomics, have moved this work towards more translational findings.

Methods: This review provides an overview of the past decade of genetically sensitive studies on adolescent development, covering both family and genomic studies in adolescents aged 10-24 years. We focus on five research themes: (1) co-occurrence or comorbidity between psychopathologies, (2) stability and change over time, (3) intergenerational transmission, (4) gene-environment interplay, and (5) psychological treatment outcomes.

Results: First, research shows that much of the co-occurrence of psychopathologies in adolescence is explained by genetic factors, with widespread pleiotropic influences on many traits. Second, stability in psychopathology across adolescence is largely explained by persistent genetic influences, whereas change is explained by emerging genetic and environmental influences. Third, contemporary twin-family studies suggest that different co-occurring genetic and environmental mechanisms may account for the intergenerational transmission of psychopathology, with some differences across psychopathologies. Fourth, genetic influences on adolescent psychopathology are correlated with a wide range of environmental exposures. However, the extent to which genetic factors interact with the environment remains unclear, as findings from both twin and genomic studies are inconsistent. Finally, a few studies suggest that genetic factors may play a role in psychological treatment response, but these findings have not yet been replicated.

Conclusions: Genetically sensitive research on adolescent psychopathology has progressed significantly in the past decade, with family and twin findings starting to be replicated at the genomic level. However, important gaps remain in the literature, and we conclude by providing suggestions of research questions that still need to be addressed.

研究综述:对过去十年关于青少年心理健康的家庭和基因组研究的综述。
背景:心理健康问题和精神病理特征是常见的,往往开始于青春期。几十年的双胞胎研究表明,遗传因素可以解释青少年精神病理中大约50%的个体差异。近年来,重大进展,特别是在基因组学方面,已经将这项工作推向了更多的转化发现。方法:本文综述了过去十年中关于青少年发育的遗传敏感研究,包括10-24岁青少年的家庭和基因组研究。我们专注于五个研究主题:(1)精神病理的共现或共病,(2)稳定性和随时间的变化,(3)代际传递,(4)基因-环境相互作用,以及(5)心理治疗结果。结果:首先,研究表明,许多青少年精神病理的共同发生可以用遗传因素来解释,遗传因素对许多特征具有广泛的多效性影响。第二,青春期精神病理的稳定性主要由持续的遗传影响来解释,而变化则由新出现的遗传和环境影响来解释。第三,当代双胞胎家庭研究表明,不同的共同发生的遗传和环境机制可能解释了精神病理学的代际传播,并且在精神病理学之间存在一些差异。第四,遗传对青少年精神病理的影响与广泛的环境暴露相关。然而,遗传因素与环境相互作用的程度仍不清楚,因为双胞胎和基因组研究的结果不一致。最后,一些研究表明遗传因素可能在心理治疗反应中起作用,但这些发现尚未被复制。结论:青少年精神病理学的遗传敏感性研究在过去十年中取得了显著进展,家庭和双胞胎的研究结果开始在基因组水平上得到复制。然而,文献中仍然存在重要的空白,我们通过提供仍需要解决的研究问题的建议来结束。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
13.80
自引率
5.30%
发文量
169
审稿时长
1 months
期刊介绍: The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including: Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents. Diagnosis: Research on the identification and classification of childhood disorders. Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health. Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders. Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health. Genetics: Genetic factors contributing to the development of childhood disorders. JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health. The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.
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