Aleix Arnau-Soler, Bénédicte L Tremblay, Yidan Sun, Anne-Marie Madore, Mathieu Simard, Elin T G Kersten, Ahla Ghauri, Ingo Marenholz, Thomas Eiwegger, Elinor Simons, Edmond S Chan, Kari Nadeau, Vanitha Sampath, Bruce D Mazer, Susan Elliott, Christine Hampson, Lianne Soller, Andrew Sandford, Philippe Begin, Jennie Hui, Bethany F Wilken, Jennifer Gerdts, Adrienn Bourkas, Anne K Ellis, Denitsa Vasileva, Ann Clarke, Aida Eslami, Moshe Ben-Shoshan, David Martino, Denise Daley, Gerard H Koppelman, Catherine Laprise, Young-Ae Lee, Yuka Asai
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引用次数: 0
Abstract
In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g., FLG, SERPINB7) and immune function (e.g., HLA, IL4). Epigenome-wide significant findings at 32 loci are also summarized as well as 14 additional loci with significance at a false discovery of < 1 × 10-4. Integration of epigenetic and genetic data is discussed in the context of disease mechanisms, many of which are shared with other allergic diseases. The potential utility of genetic and epigenetic discoveries is deliberated. In the future, genetic and epigenetic markers may offer ways to predict the presence or absence of clinical IgE-mediated food allergy among sensitized individuals, likelihood of development of natural tolerance, and response to immunotherapy.
期刊介绍:
Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality.
Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.