Citric-Acid-Modified Iron–Titanium Dioxide Nanodots for Fenton Reaction-Driven MRI Contrast Enhancement of In Vivo Hydrogen Peroxide

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Wang Qian, Shiqi Jin, Ruiyang Suo, Yi Li, Huan Ling, Shuqi Li, Ling Zhu, Kai Deng, Wenjie Sun*, Yongchang Wei* and Bo Wu*, 
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Abstract

Reactive oxygen species (ROS), including hydroxyl and superoxide radicals, play crucial roles in disease development and are recognized as indicators for cancer and inflammation. Although these radicals possess paramagnetism due to unpaired electrons, their high reactivity and low in vivo concentrations challenge MRI detectability. In this study, we utilized iron–titanium dioxide nanodots modified by citric acid (Fe-TiO2-CA) as catalysts in the Fenton reaction to efficiently convert hydrogen peroxide, a diamagnetic molecule, into paramagnetic hydroxyl radicals. This conversion maintained the concentration of hydroxyl radicals within the detectable range for MRI. Our results demonstrated that Fe-TiO2-CA significantly shortened the T1 relaxation time in H2O2 solutions. Importantly, this approach successfully enabled in vivo imaging of areas with elevated hydrogen peroxide concentrations typical of cancerous and inflamed tissues. These findings highlight the potential of Fenton reaction catalysts as innovative diagnostic tools for MRI-based detection of diseases with elevated hydrogen peroxide levels.

Abstract Image

柠檬酸修饰的铁-二氧化钛纳米点用于Fenton反应驱动的体内过氧化氢MRI对比增强
活性氧(ROS),包括羟基和超氧自由基,在疾病发展中起着至关重要的作用,被认为是癌症和炎症的指标。虽然这些自由基由于未成对电子而具有顺磁性,但它们的高反应性和低体内浓度挑战了MRI的可探测性。在本研究中,我们利用柠檬酸修饰的铁-二氧化钛纳米点(Fe-TiO2-CA)作为Fenton反应的催化剂,有效地将抗磁性分子过氧化氢转化为顺磁性羟基自由基。这种转化使羟基自由基的浓度保持在MRI可检测的范围内。我们的结果表明,Fe-TiO2-CA显著缩短了H2O2溶液中的T1弛豫时间。重要的是,这种方法成功地实现了过氧化氢浓度升高的癌变和炎症组织的体内成像。这些发现突出了Fenton反应催化剂作为基于mri检测过氧化氢水平升高疾病的创新诊断工具的潜力。
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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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