Qiang Ding, Tian Chen, Chaoxi Wu* and Shunqing Tang*,
{"title":"Immunomodulatory Nanofibrous Membrane Based on Collagen/Curdlan Acetate for Accelerated Wound Repair","authors":"Qiang Ding, Tian Chen, Chaoxi Wu* and Shunqing Tang*, ","doi":"10.1021/acsapm.4c0296810.1021/acsapm.4c02968","DOIUrl":null,"url":null,"abstract":"<p >Collagen is a key component in the extracellular matrix (ECM) with potent immunoregulatory and wound-healing functions. However, its limited processability and stability have hindered its application as a wound dressing. To this end, a composite nanofibrous membrane based on Curdlan acetate (CDA) and bovine type I collagen was developed to broaden the utility of collagen in wound repair. The CDA/collagen nanofibrous membrane (CDAColNM5) demonstrated an average fiber diameter of ∼100 nm, a tensile strength of ∼3.4 MPa, and a swelling degree of ∼540%. The composite membrane also supported the adhesion and proliferation of 3T3 fibroblast cells while upregulating the expression of pro-regenerative cytokines such as IL-6, IL-10, and TGF-β in macrophage models. The immunomodulatory and wound-healing activities of CDAColNM5 were also verified in an animal study. Therefore, these findings suggest that CDAColNM5 represents a promising option for wound management.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"6 23","pages":"14784–14793 14784–14793"},"PeriodicalIF":4.4000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Polymer Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsapm.4c02968","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Collagen is a key component in the extracellular matrix (ECM) with potent immunoregulatory and wound-healing functions. However, its limited processability and stability have hindered its application as a wound dressing. To this end, a composite nanofibrous membrane based on Curdlan acetate (CDA) and bovine type I collagen was developed to broaden the utility of collagen in wound repair. The CDA/collagen nanofibrous membrane (CDAColNM5) demonstrated an average fiber diameter of ∼100 nm, a tensile strength of ∼3.4 MPa, and a swelling degree of ∼540%. The composite membrane also supported the adhesion and proliferation of 3T3 fibroblast cells while upregulating the expression of pro-regenerative cytokines such as IL-6, IL-10, and TGF-β in macrophage models. The immunomodulatory and wound-healing activities of CDAColNM5 were also verified in an animal study. Therefore, these findings suggest that CDAColNM5 represents a promising option for wound management.
期刊介绍：
ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.
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