Near-Infrared Light Driven Reversible Photoelectrochemical Bioassay by S-Scheme All-Polymer Blends for Acetylcholinesterase Activity Monitoring

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2024-12-19 DOI:10.1021/acs.nanolett.4c05417

Ying Qin, Runshi Xiao, Wentao Xu, Han Yu, Mingwang Liu, Wenhong Yang, Rong Tan, Yuanxing Chen, Jing Wen, Xiang Peng, Wenling Gu, Chengzhou Zhu, Liuyong Hu

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Abstract

Photoelectrochemical (PEC) biosensing, recognized for its heightened sensitivity, faces limitations in its application for in vivo diagnosis due to the inefficiency of UV–visible light-driven photoactive materials in nontransparent biological samples. In this study, we investigate the potential of an S-scheme all-polymer heterojunction comprising a prototype nonfullerene polymeric acceptor (PYIT) and carbon nitride to develop a near-infrared (NIR) light-driven PEC biosensor for monitoring acetylcholinesterase activity in nontransparent human whole blood. The distinct molecular structure of PYIT enables efficient light absorption in the NIR region, enhancing sensitivity in nontransparent biological samples. The biosensor functions via a proton-dependent conversion mechanism between PYIT-OH and PYIT, leveraging the selective and reversible chemical reactivity of the moieties in backbone, eliminating the need for traditional and intricate integration of a biorecognition unit. Our findings demonstrate a direct correlation between variations in photoelectric performance and acetylcholinesterase concentration, showcasing exceptional sensitivity, selectivity, and reversibility.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.