Roseburia intestinalis-derived butyrate alleviates neuropathic pain

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-12-19 DOI:10.1016/j.chom.2024.11.013

Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Xiaodong Liu

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引用次数: 0

Abstract

Approximately 20% of patients with shingles develop postherpetic neuralgia (PHN). We investigated the role of gut microbiota in shingle- and PHN-related pain. Patients with shingles or PHN exhibited significant alterations in their gut microbiota with microbial markers predicting PHN development among patients with shingles. Functionally, fecal microbiota transplantation from patients with PHN to mice heightened pain sensitivity. Administration of Roseburia intestinalis, a bacterium both depleted in patients with shingles and PHN, alleviated peripheral nerve injury-induced pain in mice. R. intestinalis enhanced vagal neurotransmission to the nucleus tractus solitarius (NTS) to suppress the central amygdala (CeA), a brain region involved in pain perception. R. intestinalis-generated butyrate activated vagal neurons through the receptor, G protein-coupled receptor 41 (GPR41). Vagal knockout of Gpr41 abolished the effects of R. intestinalis on the NTS-CeA circuit and reduced pain behaviors. Overall, we established a microbiota-based model for PHN risk assessment and identified R. intestinalis as a potential pain-alleviating probiotic.

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源自蔷薇肠的丁酸盐可减轻神经性疼痛

大约20%的带状疱疹患者会出现带状疱疹后神经痛（PHN）。我们研究了肠道菌群在带状疱疹和phn相关疼痛中的作用。带状疱疹或PHN患者的肠道微生物群有显著变化，微生物标志物可预测带状疱疹患者PHN的发展。从功能上讲，PHN患者的粪便微生物群移植到小鼠身上可以增强疼痛敏感性。在带状疱疹患者和PHN患者中，肠道玫瑰菌（Roseburia ininalis）都已消失，给药可以减轻小鼠周围神经损伤引起的疼痛。肠菊增强迷走神经传递到孤束核（NTS）以抑制中枢杏仁核（CeA），这是一个参与疼痛感知的大脑区域。丁酸盐通过G蛋白偶联受体41 （GPR41）激活迷走神经。迷走神经敲除Gpr41可消除肠麻对NTS-CeA回路的影响，减轻疼痛行为。总的来说，我们建立了一个基于微生物群的PHN风险评估模型，并确定肠球菌是一种潜在的缓解疼痛的益生菌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.