Early childhood respiratory morbidity according to gestational age at birth: A nationwide cohort study

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-01-01 DOI:10.1016/j.rmed.2024.107913

Yishai Sompolinsky , Michal Lipschuetz , Malena Cohen-Cymberknoh , Sarah M. Cohen , Doron Kabiri , Asnat Walfisch , Simcha Yagel , Shulamit Gordon , Ziona Haklai , Yael Applbaum

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引用次数: 0

Abstract

Background

Preterm birth survivors are at risk for short- and long-term respiratory morbidity. This includes increased rates of chronic obstructive pulmonary disease and infectious morbidity. Previous studies showed increased utilization of healthcare services throughout early childhood. However, only a few large-scale studies showed the effect on respiratory morbidity throughout the full spectrum of gestational age at birth. The aim of this study was to show the healthcare burden associated with prematurity, in a large nationwide cohort.

Study design

Data regarding gestational age at birth, month and year of birth, and infant sex were gathered for all 1,762,149 infants born in Israel between January 1, 2010, and December 31, 2019. Rates of hospitalization, length of hospitalization, and emergency department visits were calculated per 1000 live births and stratified by gestational age. Poisson regression was constructed to adjust for infant sex, year and month of birth.

Results

Preterm birth occurred in 6.43 % of deliveries (n = 109,405). A negative association was found between gestational age at birth and respiratory morbidity. As gestational age at birth advances, rates of respiratory hospitalization decrease, and length of hospitalization shortens. This association continues even after full term is reached.

Conclusion

The short- and long-term effect of preterm birth poses a significant burden on healthcare systems globally, not only at birth or in infancy, but well into early childhood. These results are a call for action to stakeholders and professional organizations to increase efforts in preventing and treating preterm and early term labor.

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根据出生胎龄的早期儿童呼吸道疾病发病率：一项全国性队列研究。

背景：早产幸存者面临短期和长期呼吸系统发病的风险。这包括慢性阻塞性肺病和感染性疾病的发病率增加。以往的研究表明，早产儿在整个婴幼儿时期对医疗保健服务的利用率增加。然而，只有少数几项大规模研究显示了出生时胎龄对整个呼吸系统发病率的影响。本研究的目的是在全国范围内的大型队列中显示与早产相关的医疗负担：研究设计：收集了 2010 年 1 月 1 日至 2019 年 12 月 31 日期间在以色列出生的所有 1 762 149 名婴儿的出生胎龄、出生月份和年份以及婴儿性别数据。计算了每 1000 名活产婴儿的住院率、住院时间和急诊就诊率，并按胎龄进行了分层。构建泊松回归以调整婴儿性别、出生年份和月份：早产发生率为 6.43%（n=109,405）。出生时的胎龄与呼吸系统发病率呈负相关。随着胎龄的增加，呼吸系统住院率降低，住院时间缩短。结论：早产儿对呼吸系统的短期和长期影响都很大：早产的短期和长期影响给全球医疗保健系统带来了沉重负担，不仅在出生时或婴儿期，而且在幼儿期也是如此。这些结果呼吁利益相关者和专业组织采取行动，加大预防和治疗早产和早产的力度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.