Screening and Impact of Neuropathic Pain in Young Individuals With Sickle Cell Disease.

IF 2.4 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI:10.1002/pbc.31493

Amira Adly, Maha Mohammed, Ahmed Aboata, Ghada Wassif, Marwa Nassef, Sara Makkeyah

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引用次数: 0

Abstract

Objective: To assess the frequency of neuropathic pain (NP) and its impact in young patients with sickle cell disease (SCD).

Methods: We used the ID-Pain (ID-P) questionnaire and a bedside clinical sensory testing (CST) as screening tools for NP and performed sensory nerve conduction study (SNCS) for all the participants. The impact of pain was assessed using Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires and Pediatric Quality of Life Inventory (PedsQL) SCD module.

Results: The mean age was 12.4 years. The ID-P questionnaire revealed that 20.5% of patients likely had NP, while 10 (34%) of the participants had abnormal CST, and only two patients (4.5%) had abnormal SNCS. On the PROMIS pain scores, the mean pain intensity score was 7.9 ± 2.0. Pain interference was the most affected domain in both patients and parent proxy reports (mean ± SD T-score 63.4 ± 6.6 and 65.2 ± 6.6, respectively) which was worse than other domains including pain quality-sensory and affective, and pain behavior (median T-scores of 47.8, 63.0, and 56.2, respectively). The mean global health-related quality of life (HRQoL) score of the children was 50.3 ± 12.1 indicating poor quality of life.

Conclusion: We report the utility of simple tools like ID-P questionnaire and CST for screening of NP in young individuals with SCD.

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镰状细胞病年轻患者神经性疼痛的筛查及其影响

目的：探讨年轻镰状细胞病（SCD）患者神经性疼痛（NP）的发生频率及其影响。方法：采用ID-Pain （ID-P）问卷和床边临床感觉测试（CST）作为NP筛查工具，对所有受试者进行感觉神经传导研究（SNCS）。使用患者报告结果测量信息系统（PROMIS）问卷和儿科生活质量量表（PedsQL） SCD模块评估疼痛的影响。结果：患者平均年龄12.4岁。ID-P问卷显示20.5%的患者可能有NP， 10例（34%）的参与者有CST异常，只有2例（4.5%）的参与者有SNCS异常。在PROMIS疼痛评分上，平均疼痛强度评分为7.9±2.0分。在患者和家长代理报告中，疼痛干扰是受影响最大的领域（平均±SD t评分分别为63.4±6.6和65.2±6.6），比疼痛质量（感觉和情感）和疼痛行为（中位t评分分别为47.8、63.0和56.2）等其他领域更差。儿童总体健康相关生活质量（HRQoL）平均得分为50.3±12.1，表明生活质量较差。结论：我们报告了简单的工具如ID-P问卷和CST在年轻SCD患者中筛查NP的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.