The association between metabolic dysfunction-associated steatotic liver disease diagnosis and vasomotor symptoms in midlife women.

IF 2.8 3区 医学 Q1 OBSTETRICS & GYNECOLOGY
Wafa A Aldhaleei, Ekta Kapoor, Chrisandra Shufelt, Michael B Wallace, Juliana M Kling, Kristin Cole, Stacey J Winham, Mary S Hedges, Stephanie S Faubion
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引用次数: 0

Abstract

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and vasomotor symptoms (VMS) are associated with increased cardiovascular disease risk. Although visceral adiposity has been linked to MASLD and VMS independently, this study aimed to evaluate associations between the two in midlife women.

Methods: A cross-sectional study of women aged 45-60 years receiving primary care at one of four sites was conducted from March 1 through June 30, 2021. MASLD diagnosis was obtained utilizing the International Classification of Diseases , Ninth Revision and Tenth Revision codes. VMS burden was evaluated with the Menopause Rating Scale and categorized as severe/very severe versus none/mild/moderate. Logistic regression models were used to assess the association between VMS and diagnosed MASLD both univariately and after individually adjusting for several risk factors.

Results: A total of 4,599 women were included in the final analysis, 304 (7%) of whom had an MASLD diagnosis. On univariate analysis, women with an MASLD diagnosis were more likely to have severe/very severe VMS (odds ratio [OR], 1.50; 95% CI, 1.08-2.08; P = 0.015). However, the association between MASLD diagnosis and severe/very severe VMS was no longer statistically significant after individually adjusting for body mass index (adjusted OR, 1.36; 95% CI, 0.97-1.92) and hypertension (adjusted OR, 1.38; 95% CI, 0.99-1.93).

Conclusions: The relationship between MASLD and VMS appears to be best explained by other variables including BMI and hypertension. Although they do not appear to be directly linked, given the prevalence of bothersome VMS in midlife women, addressing VMS may enable greater adherence to lifestyle modifications as part of MASLD management.

中年妇女代谢功能障碍相关脂肪变性肝病诊断与血管舒缩症状的关系
目的:代谢功能障碍相关脂肪变性肝病(MASLD)和血管舒缩症状(VMS)与心血管疾病风险增加相关。虽然内脏肥胖与MASLD和VMS独立相关,但本研究旨在评估中年女性两者之间的关联。方法:在2021年3月1日至6月30日期间,对在四个地点之一接受初级保健的45-60岁女性进行了横断面研究。MASLD诊断是利用国际疾病分类第九版和第十版代码获得的。使用绝经评分量表评估VMS负担,并将其分为严重/非常严重与无/轻度/中度。Logistic回归模型用于评估VMS与诊断的MASLD之间的关联,包括单因素和单独调整几个危险因素后。结果:共有4599名女性被纳入最终分析,其中304名(7%)被诊断为MASLD。在单因素分析中,诊断为MASLD的女性更有可能患有严重/非常严重的VMS(优势比[OR], 1.50;95% ci, 1.08-2.08;P = 0.015)。然而,在单独调整体重指数后,MASLD诊断与严重/非常严重VMS之间的关联不再具有统计学意义(调整OR, 1.36;95% CI, 0.97-1.92)和高血压(校正OR, 1.38;95% ci, 0.99-1.93)。结论:MASLD与VMS之间的关系似乎最好由BMI和高血压等其他变量来解释。尽管它们似乎没有直接联系,但鉴于烦人的VMS在中年妇女中普遍存在,解决VMS可能会使人们更坚持将生活方式改变作为MASLD管理的一部分。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
330
审稿时长
3-8 weeks
期刊介绍: ​Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.
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