Autistic traits are associated with the presence of post-traumatic stress symptoms and suicidality among subjects with autism spectrum conditions and Anorexia nervosa

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-01-01 DOI:10.1016/j.jpsychires.2024.12.006

Liliana Dell'Osso , Ivan Mirko Cremone , Ilaria Chiarantini , Benedetta Nardi , Cristiana Pronestì , Giulia Amatori , Enrico Massimetti , Maria Salvina Signorelli , Matteo Rocchetti , Giovanni Castellini , Eugenio Aguglia , Pierluigi Politi , Valdo Ricca , Stefano Pini , Barbara Carpita

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引用次数: 0

Abstract

Introduction

Recently, growing attention has been paid to the presence of undetected Autism Spectrum Disorder (ASD) and subthreshold autistic traits (ATs) among females, and on their gender specific manifestation. In particular, the recent literature focused on the overlap between autism spectrum and eating disorders, which share with ASD not only features such as of cognitive inflexibility but also a link with trauma- and stress-related disorders. In this framework, we aimed to assess the interaction between ATs, stress- or trauma-related symptoms, and the risk of suicidality in subjects with different mental conditions.

Methods

184 subjects were divided in three diagnostic groups: Broad autism phenotype (BAP), Anorexia Nervosa (AN) and Healthy Controls (HCs) and assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) questionnaire, the Trauma and Loss Spectrum – Self Report (TALS – SR) questionnaire and the Mood Spectrum – Self Report (MOODS – SR) questionnaire.

Results

AN subjects reported notable ATs reinforcing the hypothesis that AN might represent an atypical ASD manifestation more common in women. Furthermore, both AN and BAP subjects showed a considerable presence of trauma/stress associated symptoms. The dimension of trauma/stress related symptoms also appeared to be associated with ATs, and to significantly mediate the relationship between ATs and suicidality risk. Lastly, AN were found to have a stronger correlation with the presence of post-traumatic stress symptoms.

Conclusions

the results support the presence of a link between ATs and AN. Moreover, AN seems to be more strongly associated with post-traumatic stress symptoms than BAP. ATs and trauma/stress related symptoms may interact in shaping suicidality risk in these patients.

查看原文本刊更多论文

自闭症特征与自闭症谱系条件和神经性厌食症患者的创伤后应激症状和自杀倾向有关。

近年来，人们越来越关注未被发现的自闭症谱系障碍（ASD）和亚阈值自闭症特征（ATs）在女性中的存在及其性别特异性表现。特别是，最近的文献集中在自闭症谱系和饮食失调之间的重叠，这与ASD不仅具有认知缺乏灵活性等特征，而且还与创伤和压力相关的疾病有关。在这个框架中，我们的目的是评估不同精神状态的受试者的ATs、压力或创伤相关症状和自杀风险之间的相互作用。方法：将184名受试者分为广义自闭症表型组（BAP）、神经性厌食症组（AN）和健康对照组（hc） 3个诊断组，采用成人自闭症阈下谱（AdAS）问卷、创伤与丧失谱-自我报告（tas - SR）问卷和情绪谱-自我报告（心境- SR）问卷进行评估。结果：AN受试者报告了显著的ATs，强化了AN可能代表女性中更常见的非典型ASD表现的假设。此外，AN和BAP受试者都表现出相当多的创伤/应激相关症状。创伤/压力相关症状的维度似乎也与ATs相关，并显著介导ATs与自杀风险之间的关系。最后，AN被发现与创伤后应激症状的存在有更强的相关性。结论：结果支持ATs和AN之间存在联系。此外，AN似乎比BAP与创伤后应激症状有更强的相关性。ATs和创伤/压力相关症状可能相互作用，形成这些患者的自杀风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;