Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice.

IF 3.4 3区生物学 Q1 Agricultural and Biological Sciences

Botanical Studies Pub Date : 2024-12-18 DOI:10.1186/s40529-024-00443-x

Chang-Hang Yang, Cai-Wei Li, Yi-Yan Sie, Liang-Chieh Chen, Yu-Hsiang Yuan, Wen-Chi Hou

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引用次数: 0

Abstract

Background: Hispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked one of the top ten leading causes of death worldwide. Little is known about the effects of hispolon on delaying AD progression.

Results: The hispolon (No.1) and its six structural analogs (No.2 to No.7) were assayed by antioxidant, anti-acetylcholinesterase activities and anti-amyloid-β_1-42-peptide aggregations. The No.1, No.6, and No.7 were selected for further molecular docking with acetylcholinesterase and core fragments of amyloid-β-peptide, and also showed capacities to recover cell viabilities in methylglyoxal-treated SH-SY5Y cells and also to enhance neurite outgrowths in PC12 cells. The daily pre-treatments of No.1, No.6, and No.7 for 10-days (40 mg/kg/day) showed to improve learning dysfunctions in scopolamine-induced ICR mice by passive avoidance tests.

Conclusion: The hispolon in the fungus sang-huang might be beneficial to develop functional foods or as lead compounds for treating degenerative disorders.

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组蛋白及其类似物体外抗氧化、抗乙酰胆碱酯酶和抗淀粉样β肽聚集，并改善东莨菪碱诱导的ICR小鼠的学习和记忆功能。

背景：从药用蘑菇黄（Phellinus linteus）中提取的一种生物活性酚类化合物Hispolon已被报道具有抗癌和抗炎活性。阿尔茨海默病（AD）是全球十大主要死亡原因之一。我们对hispolon延缓AD进展的作用知之甚少。结果：用抗氧化活性、抗乙酰胆碱酯酶活性和抗淀粉样蛋白-β1-42肽聚集活性测定了组蛋白蛋白1号及其6个结构类似物（2 ~ 7号）。选择1号、6号和7号与乙酰胆碱酯酶和淀粉样β肽核心片段进行进一步的分子对接，也显示出在甲基乙二醛处理的SH-SY5Y细胞中恢复细胞活力的能力，并增强PC12细胞的神经突生长。被动回避试验显示，1号、6号和7号每日预处理（40 mg/kg/天）10 d后，东莨菪碱诱导的ICR小鼠学习功能障碍得到改善。结论：桑黄菌中的组蛋白可开发功能食品或作为治疗退行性疾病的先导化合物。

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来源期刊

Botanical Studies 生物-植物科学

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

2.4 months

期刊介绍： Botanical Studies is an open access journal that encompasses all aspects of botany, including but not limited to taxonomy, morphology, development, genetics, evolution, reproduction, systematics, and biodiversity of all plant groups, algae, and fungi. The journal is affiliated with the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.