Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China.

IF 6.2 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ecotoxicology and Environmental Safety Pub Date : 2025-01-15 Epub Date: 2024-12-16 DOI:10.1016/j.ecoenv.2024.117540
Keyi Wu, Weidong Fan, Jing Wei, Jianyun Lu, Xiaowei Ma, Zelin Yuan, Zhiwei Huang, Qi Zhong, Yining Huang, Fei Zou, Xianbo Wu
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引用次数: 0

Abstract

Background: Although the link between fine particulate matter (PM2.5) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM2.5 on ILI remains unclear. This study aims to explore this effect in Guangzhou, China.

Methods: Daily data on ILI cases, PM2.5 levels, and specific PM2.5 constituents (black carbon [BC], chlorine [Cl-], ammonia [NH4+], nitrate [NO3-], and sulfate [SO42-]) in Guangzhou, China, were collected for the period of 2014-2019. Additionally, data on gaseous pollutants and meteorological conditions were obtained. By using quasi-Poisson regression models, the association between exposure to PM2.5 and its constituents and ILI risk was estimated. Stratified subgroup analyses were performed by gender, age, and season to explore in depth the effects of these factors on disease risk.

Results: Single-pollutant modeling results showed that an increase of one interquartile range (IQR) in Cl-, SO42-, PM2.5, NH4+, BC, and NO3- corresponded to relative risks of ILI of 1.046 (95 % CI: 1.004, 1.090) (lag03), 1.098 (95 % CI: 1.058, 1.139) (lag01), 1.091 (95 % CI: 1.054, 1.130) (lag02), 1.093 (95 % CI: 1.049, 1.138) (lag02), 1.111 (95 % CI: 1.074, 1.150) (lag03), and 1.103 (95 % CI: 1.061, 1.146) (lag03), respectively. Notably, the association between ILI and BC remained significant even after adjusting for PM2.5 mass. Subgroup analyses indicated that individuals aged 5-14 and 15-24 years may exhibit higher sensitivity to BC and Cl- exposure than other individuals. Furthermore, stronger associations were observed during the cold season than during the warm season.

Conclusions: Results showed that the mass and constituents of PM2.5 were significantly correlated with ILI. Specifically, the carbonaceous fractions of PM2.5 were found to have a pronounced effect on ILI. These findings underscore the importance of implementing effective measures to reduce the emission of specific sources of PM2.5 constituents to mitigate the risk of ILI. Nevertheless, limitations such as potential exposure misclassification and regional constraints should be considered.

广州细颗粒物及其化学成分对流感样疾病的影响
背景:虽然细颗粒物(PM2.5)与流感样疾病(ILI)之间的联系已经确立,但PM2.5的化学成分对ILI的影响尚不清楚。本研究旨在探讨中国广州的这种效应。方法:收集2014-2019年广州地区ILI病例、PM2.5水平和PM2.5特定成分(黑碳[BC]、氯[Cl-]、氨[NH4+]、硝酸盐[NO3-]和硫酸盐[SO42-])的日常数据。此外,还获得了气体污染物和气象条件的数据。采用准泊松回归模型,估计PM2.5及其成分暴露与ILI风险之间的关系。按性别、年龄和季节进行分层亚组分析,以深入探讨这些因素对疾病风险的影响。结果:单污染物模型结果显示,Cl-、SO42-、PM2.5、NH4+、BC和NO3-增加一个四分位数范围(IQR), ILI的相对危险度分别为1.046(95 % CI: 1.004, 1.090) (lag03)、1.098(95 % CI: 1.058, 1.139) (lag01)、1.091(95 % CI: 1.054, 1.130) (lag02)、1.093(95 % CI: 1.049, 1.138) (lag02)、1.111(95 % CI: 1.074, 1.150) (lag03)和1.103(95 % CI: 1.061, 1.146) (lag03)。值得注意的是,即使在调整PM2.5质量后,ILI和BC之间的关联仍然显著。亚组分析表明,5-14岁和15-24岁的个体可能比其他个体对BC和Cl暴露表现出更高的敏感性。此外,在寒冷季节比在温暖季节观察到更强的关联。结论:PM2.5的质量和成分与ILI呈显著相关。具体而言,PM2.5的碳质组分对ILI有显著影响。这些发现强调了采取有效措施减少特定来源的PM2.5成分排放以减轻ILI风险的重要性。然而,应考虑潜在暴露、错误分类和区域限制等局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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