Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion.

IF 6.2 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ecotoxicology and Environmental Safety Pub Date : 2025-01-15 Epub Date: 2024-12-16 DOI:10.1016/j.ecoenv.2024.117516
Meng Lin, Yutong Wang, Xiaoye Wang, Lailai Yan, Linlin Wang, Chan Tian
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Abstract

Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion in Peking University Third Hospital. The concentrations of six alkali and alkaline earth elements in chorionic villi were measured using inductively coupled plasma mass spectrometry (ICP-MS). Through using logistic regression, Bayesian kernel machine regression (BKMR) and Weighted quantile sum regression (WQS) model, we assessed single and mixed exposure effects of alkali and alkaline earth elements on spontaneous abortion. In terms of the individual effect, high concentration group of barium (Ba) increased the risk of spontaneous abortion by 150 % (95 % CI: 1.38-4.51), whereas rubidium (Rb), cesium (Cs) and Magnesium (Mg) all clearly demonstrated dose dependency in reducing the incidence of spontaneous abortion. The BKMR model demonstrated that as the mixed exposure percentile increased, the likelihood of spontaneous abortion decreased almost linearly. For every quartile increasing in the WQS index, the risk of spontaneous abortion decreased (OR: 0.21, 95 % CI: 0.13-0.33), with Mg and Rb having the highest weights at 0.587 and 0.367, respectively. According to our findings, there were negative dose-response relationships between Mg and Rb levels and risk for spontaneous abortion, but exposure to higher concentration of Ba in the chorionic villi was positively associated with the risk of it.

绒毛膜绒毛中碱和碱土元素与自然流产风险的关系。
据报道,暴露于特定碱和碱土元素(AEs/AEEs)与自然流产风险增加有关。然而,子宫内暴露的直接证据是缺失的。因此,我们在北京大学第三医院自然流产或人工流产后采集绒毛膜绒毛。采用电感耦合等离子体质谱法(ICP-MS)测定了绒毛膜绒毛中6种碱和碱土元素的浓度。采用logistic回归、贝叶斯核机回归(BKMR)和加权分位数和回归(WQS)模型,评价碱和碱土元素单独和混合暴露对自然流产的影响。在个体效应方面,高浓度钡(Ba)组使自然流产风险增加150 %(95 % CI: 1.38-4.51),而铷(Rb)、铯(Cs)和镁(Mg)在降低自然流产发生率方面均明显表现出剂量依赖性。BKMR模型表明,随着混合暴露百分位数的增加,自然流产的可能性几乎呈线性下降。WQS指数每增加四分位数,自然流产的风险降低(OR: 0.21, 95 % CI: 0.13-0.33),其中Mg和Rb的权重最高,分别为0.587和0.367。根据我们的研究结果,Mg和Rb水平与自然流产风险之间存在负剂量反应关系,但暴露于绒毛膜绒毛中高浓度的Ba与自然流产风险呈正相关。
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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