Controllable Self-Assembly of V═O Metalloradical Complex with Intramolecular Charge Transfer for Enhanced NIR-II Fluorescence Imaging-Guided Photothermal Therapy

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Jianshuai Bao, Zengyin Li, Deliang Wang, Jiefei Wang, Guan Huang, Jianlei Qian, Xiaoyan Yang, Peng-Cheng Duan, Sheng Zhang, Feng Bai, Yong Zhong
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引用次数: 0

Abstract

Near-infrared second region (NIR-II) fluorescence imaging provides enhanced tissue penetration, achieving efficient NIR-II fluorescence and photoacoustic imaging (PA)-guided photothermal therapy (PTT) all in one material remains a challenging yet promising approach in cancer treatment. Herein, open-shell V═O metalloradical complex (VONc) is self-assembled into VONc nanospheres (VONc NPs). VONc NPs exhibit light absorption from 300 to 1400 nm, fluorescence spectra ranging from 900 to 1400 nm, and a distinct fluorescence signal even at 1550 nm. Moreover, VONc NPs exhibit outstanding photostability and a higher photothermal conversion efficiency of 46.6% than that of closed-shell zinc naphthalocyanine nanorods (ZnNc NRs). V═O centered metalloradical serves as transient electron-withdrawing groups to facilitate charge transfer (CT), introducing additional nonradiative energy dissipation pathways and enhancing efficient heat generation. In vitro experiments of VONc NPs indicate that a highly effective photothermal action causes harm to both mitochondria and lysosomes, resulting in the death of tumor cells, closed-shell ZnNc NPs exhibit almost no cell killing as contrast. In vivo anti-tumor therapy results of VONc NPs demonstrate excellent NIR-II fluorescence imaging-guided PTT against tumors with a favorable biosafety profile. “Centered metalloradical boosting CT” toward open-shell metal complexes provides significant insight for developing single-material integrated nanosystems for diagnostic and therapeutic applications.

Abstract Image

带分子内电荷转移的V = O金属络合物在增强NIR-II荧光成像引导光热治疗中的可控自组装。
近红外第二区(NIR-II)荧光成像提供了增强的组织穿透性,在一种材料中实现有效的NIR-II荧光和光声成像(PA)引导的光热治疗(PTT)仍然是癌症治疗中具有挑战性但有前景的方法。在这里,开壳层的V = O金属络合物(VONc)被自组装成VONc纳米球(VONc NPs)。VONc NPs的光吸收范围为300 ~ 1400 nm,荧光光谱范围为900 ~ 1400 nm,即使在1550 nm处也有明显的荧光信号。此外,VONc纳米棒具有良好的光稳定性,其光热转换效率比闭壳型萘菁锌纳米棒(ZnNc NRs)高46.6%。以V = O为中心的金属基团充当瞬态吸电子基团,以促进电荷转移(CT),引入额外的非辐射能量耗散途径并增强有效的热生成。VONc NPs的体外实验表明,高效的光热作用对线粒体和溶酶体均造成伤害,导致肿瘤细胞死亡,而闭壳ZnNc NPs几乎没有细胞杀伤作用。VONc NPs的体内抗肿瘤治疗结果表明,NIR-II荧光成像引导的PTT对肿瘤具有良好的生物安全性。针对开壳金属配合物的“中心金属增强CT”为开发用于诊断和治疗的单材料集成纳米系统提供了重要的见解。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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