Functional Segregation-Integration Preference Configures the Cognitive Decline Against Cerebral Small Vessel Disease: An MRI Study

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2024-12-17 DOI:10.1111/cns.70162

Wentao Hu, Yao Wang, Zhenhui Xie, Mianxin Liu, Xu Han, Ying Hu, Xingrui Wang, Yongming Dai, Qun Xu, Yan Zhou

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Abstract

Introduction

Cerebral small vessel disease (CSVD) is highly prevalent in elder individuals, and its variable cognitive outcomes indicate some cognitive reserve mechanisms. Contribution from functional network features is still unclear. Here we explore how functional segregation-integration preference influences the cognitive changes against CSVD.

Materials and Methods

A total of, 271 CSVD patients were included, all underwent MRI scans including routine and resting-state functional MRI (rs-fMRI). Hierarchical balance index (H_B) was obtained from the rs-fMRI connectivity using eigenmode-based approach. Individuals were classified into segregated and integrated groups according to negative and positive H_B. A composite CSVD lesion score was calculated from imaging findings. Global and five specific cognitive functions were assessed.

Results

Hierarchical regression analysis revealed negative contribution from lesion load to global and all cognitive domains (β = −0.22~−0.35, ∆R² = 0.046~0.112, all p < 0.001). Inclusion of H_B did not show significant contribution (all p > 0.05), but interaction between H_B and lesion score was significantly associated with global (β = −0.27, ∆R² = 0.013, p = 0.034) and execution score (β = −0.34, ∆R² = 0.023, p = 0.002). Integrated patients show significant better global cognitive (23.9 ± 3.9 vs. 25.5 ± 3.1, p = 0.044) and executive ability (0.235 ± 0.678 vs. 0.535 ± 0.688, p = 0.049) at mild damage stage, visuospatial (−0.001 ± 0.804 vs. 0.379 ± 0.249, p = 0.034) and language ability (−0.133 ± 0.849 vs. 0.218 ± 0.704, p = 0.037) at moderate damage stage. Cross-overs of cognitive scores were observed. Significant better execution (−0.277 ± 0.717 vs. −0.675 ± 0.883, p = 0.027) was found in severe damage stage for segregated patients.

Conclusion

Thus, we concluded that integrated network contributes to cognitive resilience in mild and moderate but not in severe damage stages.

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.