Xianfeng Chu, Xiaowen Dou, Jiaying Yu, Junpeng Zhou, Di Ma, Miao Miao, Shaojun Hu, Kai Sun, Shihong Zhu, Qi Liu, Xiuming Zhang, Yong Jiang, Zhi-Fei Wang
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引用次数: 0
Abstract
In this study, we present a novel chemical biology strategy that leverages the reductive metabolic pathways of cancer cells to develop a new approach for synthesizing polymers in nonstrictly anaerobic conditions. This method utilizes the reductive metabolism of cancer cells to reduce Cu(II) to Cu(I), enabling Cu(I)-catalyzed controlled radical polymerization with poly(ethylene glycol) methyl ether methacrylate (MAPEGOMe) monomer, producing polymers with low dispersity (1.28-1.38). Furthermore, we found that this method could use MAPEGOMe as a monomer to in situ form a polymer layer on the initiator-modified cell surface, achieving a cell surface engineering modification. This study reveals the broad application value and potential of cancer cell metabolism-mediated controlled radical polymerization in the fields of chemical biology and polymer science.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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