Mechanisms of the Antimicrobial Action of Fatty Acids: A Review

Abstract

Among the diverse biological activities of fatty acids (FAs), the ability to kill or inhibit the growth of microorganisms can be distinguished. Even though the antibacterial mechanisms of fatty acids are not fully understood, the most common target of action is the cell membrane, where FAs mediate an increase in permeability and subsequent cell lysis, leading to disruption of the electron transport chain, uncoupling of oxidative phosphorylation, and inhibition of enzymatic activity and nutrient intake. In addition to acting on cell membranes, FAs can disrupt the metabolic processes of microorganisms, inhibit DNA/RNA replication, and affect the expression of virulence genes. In addition, nontraditional mechanisms of the antimicrobial action of FAs are currently being described, such as the inhibition of horizontal gene transfer, quorum sensing, and the disruption of the efflux pump. The variety of antimicrobial mechanisms and the wide range of their activity determine the high biotechnological potential of fatty acids and make further studies of the mechanisms of action on biological systems relevant.