Molecular Quantum (MolQ) Communication Channel in the Gut-Brain Axis Synapse

IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Pub Date : 2024-09-17 DOI:10.1109/TMBMC.2024.3462727

Bitop Maitra;Ozgur B. Akan

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Abstract

The gut-brain axis is the communication link between the gut and the brain. Although it is known that the gut-brain axis plays a pivotal role in homeostasis, its overall mechanism is still not known. However, for neural synapses, classical molecular communication is described by the formation of ligand-receptor complexes, which leads to the opening of ion channels. Moreover, there are some conditions that need to be fulfilled before the opening of the ion channel. In this study, we consider the gut-brain axis, where neurotransmitters diffuse through the synaptic cleft, considering molecular communication. On the vagus nerve (VN) membrane, i.e., the post-synaptic membrane of the synapse, it undergoes a quantum communication (QC), which initiates the opening of the ion channel, thus initiating the communication signal from the gut to the brain. It evolves a new paradigm of communication approach, Molecular Quantum (MolQ) communication. Based on the QC model, we theoretically analyze the output states, and QC is simulated considering the incoming neurotransmitter’s concentration and validated by analyzing the entropy and the mutual information of the input, i.e., neurotransmitter’s concentration, and output, i.e., ion channel opening.

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肠-脑轴突触中的分子量子（MolQ）通信通道

肠脑轴是肠和大脑之间的沟通纽带。虽然已知肠脑轴在体内平衡中起关键作用，但其整体机制尚不清楚。然而，对于神经突触来说，经典的分子通信是通过配体-受体复合物的形成来描述的，这导致离子通道的开放。此外，在离子通道打开之前还需要满足一些条件。在这项研究中，我们考虑肠-脑轴，神经递质通过突触间隙扩散，考虑分子通讯。在迷走神经（VN）膜上，即突触的突触后膜上，进行量子通信（QC），量子通信启动离子通道的打开，从而启动肠道到大脑的通信信号。它发展了一种新的通信方法范式——分子量子通信。在QC模型的基础上，从理论上分析了输出状态，考虑输入神经递质浓度对QC进行了仿真，并通过分析输入神经递质浓度和输出离子通道开度的熵和互信息进行了验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Mathematics-Modeling and Simulation

CiteScore

3.90

自引率

13.60%

发文量

期刊介绍： As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.