Advances in Injectable Polymeric Biomaterials and Their Contemporary Medical Practices

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-29 DOI:10.1021/acsabm.4c0100110.1021/acsabm.4c01001

Sophia Beilharz, Mithun Kumar Debnath, Daniele Vinella, Andrew J. Shoffstall and Metin Karayilan*,

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引用次数: 0

Abstract

Injectable biomaterials have been engineered to operate within the human body, offering versatile solutions for minimally invasive therapies and meeting several stringent requirements such as biocompatibility, biodegradability, low viscosity for ease of injection, mechanical strength, rapid gelation postinjection, controlled release of therapeutic agents, hydrophobicity/hydrophilicity balance, stability under physiological conditions, and the ability to be sterilized. Their adaptability and performance in diverse clinical settings make them invaluable for modern medical treatments. This article reviews recent advancements in the design, synthesis, and characterization of injectable polymeric biomaterials, providing insights into their emerging applications. We discuss a broad spectrum of these materials, including natural, synthetic, hybrid, and composite types, that are being applied in targeted drug delivery, cell and protein transport, regenerative medicine, tissue adhesives, injectable implants, bioimaging, diagnostics, and 3D bioprinting. Ultimately, the review highlights the critical role of injectable polymeric biomaterials in shaping the future of medical treatments and improving patient outcomes across a wide range of therapeutic and diagnostic applications.

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可注射高分子生物材料的研究进展及其当代医学应用

可注射的生物材料已经被设计成在人体内运作，为微创治疗提供了多种解决方案，并满足几个严格的要求，如生物相容性，生物可降解性，易于注射的低粘度，机械强度，注射后快速凝胶化，治疗剂的控制释放，疏水性/亲水性平衡，生理条件下的稳定性，以及灭菌能力。它们在不同临床环境中的适应性和表现使它们成为现代医学治疗的无价之宝。本文综述了可注射高分子生物材料的设计、合成和表征方面的最新进展，并提供了对其新兴应用的见解。我们讨论了这些材料的广泛范围，包括天然、合成、混合和复合类型，这些材料正在应用于靶向药物输送、细胞和蛋白质运输、再生医学、组织粘合剂、可注射植入物、生物成像、诊断和3D生物打印。最后，综述强调了可注射高分子生物材料在塑造未来医学治疗和改善患者预后方面的关键作用，这些应用范围广泛，包括治疗和诊断应用。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.